Abstract 20319: Aging is Associated With Abnormal Wave Hemodynamics in the Carotid Artery
Background: Advanced age is associated with microvascular disease in the brain. Recent evidence suggest that abnormal central pulsatile hemodynamics play a role in the pathogenesis of microvascular disease in the brain, since this high-flow organs is particularly sensitive to excessive pulsatility due to its low microvascular resistance. However, how aging changes the pulsatile hemodynamic patterns in the carotid artery is incompletely understood, particularly in middle-age.
Hypothesis: Aging is associated with abnormal wave patterns in the carotid artery.
Methods: We studied 2168 men and women participants in the community-based Asklepios study in Belgium (mean age=45.9±6 years).We measured carotid pressure and flow with arterial tonometry and Doppler ultrasound, respectively. Wave intensity analysis was applied to quantify the energy in forward- and backward-traveling carotid waves.
Results: Despite being associated with increased carotid pulse pressure (beta=0.22; P<0.0001) and mean flow velocity (β=0.05; P=0.02), age was negatively associated with the intensity of the forward compression wave generated by the heart (β=-0.10; P<0.0001). However, age (β=0.15; P<0.0001) was also associated with increased energy of the forward-traveling decompression (suction), known to originate from the heart in late systole as a result of blood deceleration/inertia.Variability in this late systolic forward-traveling suction wave was a much more important predictor of the hydraulic oscillatory power in the carotid artery (β=0.53; P<0.0001). Age was associated with a greater total hydraulic power (β=0.12; P<0.001), greater oscillatory power (β=0.23; P<0.0001), and a greater oscillatory power expressed as a proportion of total power (β=0.23; P<0.0001). Age was not associated with the intensity of backward-traveling waves originating distal to the carotid artery).
Conclusion: Aging is associated with an increased late systolic forward suction wave energy in the carotid artery. This suction wave traveling from the heart to the brain is a novel mechanism that increases oscillatory energy in the carotid artery with aging, and which may contribute to age-related microvascular disease in the brain.
Author Disclosures: J.A. Chirinos: None. M. De Buyzere: None. E. Rietzschel: None. T. Gillebert: None. R. Verma: None. S. Jain: None. P. Segers: None.
This research has received full or partial funding support from the American Heart Association.
- © 2014 by American Heart Association, Inc.