Abstract 20242: Right Ventricular Mechanics in Pulmonary Hypertension Evaluated With Cardiac Magnetic Resonance Feature Tracking
Background: Prognosis in pulmonary hypertension (PH) is related to right ventricular (RV) function. We evaluated the feasibility of a novel CMR-based feature-tracking (FT) technique for the evaluation of RV mechanics in PH.
Methods: We retrospectively evaluated 116 consecutive patients (age 52.2±12 years, 73.6% females) referred to CMR due to suspected chronic PH who also underwent right heart catheterization. We included all etiologies except for left heart disease and systemic-to-pulmonary shunt. Using dedicated FT software (TomTec©), RV systolic strain was quantified from standard steady-state free precession cine images. Peak longitudinal strain (LS) was measured from 4-chamber cine views. Peak circumferential strain (CS) was obtained as the average of mean peak CS from basal, mid, and apical short-axis views. PH was defined as mean pulmonary artery pressure (mPAP) ≥25 mmHg. Mild, moderate, and severe PH were defined as mPAP=25-35, 36-45, and >45 mmHg, respectively.
Results: FT evaluation of RV strain was feasible in 110 (95%) patients. In 6 cases strain could not be measured due to breathing motion and/or arrhythmia. PH was present in 93 (84.5%) patients: 30 mild, 24 moderate, and 39 severe. Mean LS and CS were reduced in patients with PH (Table). RV LS decreased with increasing PH severity, particularly at earlier PH stages (Figure).
Conclusion: Quantification of RV mechanics using CMR-based FT is feasible in PH. RV LS and CS decreases as PH severity increases, and reductions in LS are proportionally more marked in early disease stages. Thus, FT may have a role in monitoring RV function or detecting early degree of dysfunction.
Author Disclosures: M. M. de Siqueira: None. V. Rolim S. Fernandes: None. E. Pozo Osinalde: None. K. Modesto: None. A. Jacobi: None. M. Cham: None. B. Jauregui Garrido: None. A. Caixeta: None. V. Fuster: None. J. Narula: None. J. Sanz: None.
- © 2014 by American Heart Association, Inc.