Abstract 20168: Right Ventricular Global Longitudinal Strain is Correlated With Cardiovascular Magnetic Resonance Ejection Fraction and Provides Prognostic Value in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Introduction: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by functional abnormalities of the right ventricular (RV). RV ejection fraction (EF) determined by cardiac magnetic resonance (CMR) imaging is accepted as gold standard measure of RV systolic function.
Hypothesis: RV global longitudinal strain (GLS) by 2-dimensional speckle tracking echocardiography (2DSTE) is correlated with CMR-RVEF, and associated with cardiac events in patients with ARVC.
Methods: We studied 50 patients referred with suspected ARVC. Of them, 19 patients (Group A) were diagnosed as ARVC, while remaining 31 patients (Group B) were not diagnosed due to not meeting criteria. All patients underwent CMR for measurements of RVEF, and echocardiography with conventional assessment including tricuspid annular plane systolic excursion (TAPSE), RV end-diastolic and end-systolic area (RVEDA, RVESA) and RV fractional area change (RVFAC), and with 2DSTE analyses of GLS which was expressed as the absolute value. The cardiac events, defined as death, hospitalization for heart failure, fatal arrhythmia and appropriate defibrillator shock, were followed up for patients in Group A.
Results: Patients in Group A had significantly smaller values of TAPSE, RVFAC, GLS and RVEF and significantly greater values of RVESV compared with patients in Group B (p<0.05 for all), while there were no significant differences in RVEDV between 2 groups. GLS were correlated with RVEF (P=0.001, r=0.4) as with RVEDA, RVESA, RVFAC and TAPSE (p<0.01 for all). 4 appropriate defibrillator shocks were observed during averaged 724 days followed-up period in Group A. Dividing patients in Group A into 2 groups with median value of CMR-RVEF or GLS, Kaplan-Meier curve analysis revealed that GLS was significantly associated with outcome (P=0.02), while CMR-RVEF was not.
Conclusions: GLS in the RV was significantly correlated with CMR-RVEF, and was associated with cardiac events in patients with ARVC.
Author Disclosures: T. Onishi: None. K. Yoshii: None. M. Tsuru: None. A. Shimane: None. K. Okajima: None. Y. Taniguchi: None. H. Kawai: None.
- © 2014 by American Heart Association, Inc.