Abstract 20071: Patients with Human Immunodeficiency Virus on Chronic Treatment Have Increased Carotid Artery Wall Thickness on Magnetic Resonance Imaging
Introduction: Patients with human immunodeficiency virus (HIV) infection have an elevated risk of stroke.
Hypothesis: Subjects with HIV on chronic highly active antiretroviral therapy (HAART) have increased carotid artery wall thickness on magnetic resonance imaging (MRI).
Methods: We compared carotid artery wall thickness between 26 individuals with HIV on chronic HAART and 20 controls without HIV, using 3.0-T non-contrast MRI. Inclusion criteria included males aged 35-55 years, and chronic HAART (≥3 years) among HIV-seropositive subjects; those with known cardiovascular disease or diabetes were excluded.
Results: Between male subjects with HIV and male controls, there were no differences in age (47.8±5.0 vs. 47.8±4.7 years, p=0.19) or cardiovascular risk factors (p>0.05 for each). Mean wall thickness was increased in those with HIV versus controls for the left (0.88±0.08 vs. 0.83±0.08 mm, p=0.03) and right (0.90±0.10 vs. 0.85±0.07 mm, p=0.046) common carotid arteries. Among individuals with HIV, variables independently associated with increased carotid artery wall thickness include lipoaccumulation [+0.09 mm, 95% confidence interval (CI) 0.03 to 0.14, p=0.003], Framingham risk score ≥5% (+0.07 mm, 95% CI 0.01 to 0.12, p=0.02), and increased duration of protease inhibitor therapy (+0.03 mm per 5 years, 95% CI 0.01 to 0.06, p=0.02).
Conclusions: Individuals with HIV on chronic HAART have increased carotid artery wall thickness as compared to similar controls. Furthermore, the presence of lipoaccumulation and duration of protease inhibitor therapy are associated with greater wall thickness. Future studies are needed to determine whether these findings are related to the increased stoke risk associated with HIV.
Author Disclosures: T.M. LaBounty: None. W. Hardy: None. F. Zhaoyang: None. R. Yumul: None. D. Li: None. R. Dharmakumar: None. A.H. Conte: None.
- © 2014 by American Heart Association, Inc.