Abstract 19640: Galectin-3 and Risk of Stroke: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort
Introduction: Galectin-3 is a biomarker of atherosclerotic disease associated with risk of heart failure, and may therefore be a useful marker for stroke risk.
HYPOTHESIS: Galectin-3 is associated with stroke risk in a biracial cohort.
METHODS: REGARDS enrolled and examined 30,239 US participants in 2003-07 (41% black, 59% white, 55% living in the southeastern stroke belt). Baseline galectin-3 was measured in 594 subjects with incident stroke and a 947 participant cohort random sample (CRS). In the CRS, sample weighting was used to estimate baseline associations of galactin-3 with cardiovascular risk factors. Cox proportional hazards models were used to calculate hazard ratios (HR) of stroke by quartiles of galectin-3.
RESULTS: In the CRS, baseline galectin-3 was higher with older age, black race, female sex, hypertension, diabetes mellitus, chronic kidney disease (estimated glomerular filtration rate <60ml/min/1.73m2) and in those who developed incident stroke. Participants in the 4th versus 1st quartile of galectin-3 had a 2.3-fold increased stroke risk (95% CI 1.6, 3.3). Adjustment for age, race, and sex attenuated this HR to 1.3 (CI 0.9, 1.8). There was a suggestive difference in results by age (p interaction galectin-3*age =0.08). Among those younger than age 64, baseline galectin-3 in the 2nd-4th quartiles was associated with increased stroke risk in a fully adjusted model, but this was not the case among older participants (table).
CONCLUSION: Galectin-3 was associated with incident stroke in younger, but not older individuals. More research is needed to determine the significance of this finding to stroke etiology.
Author Disclosures: Z. Agarwal: None. P.W. Callas: None. B. Kissela: None. N. Jenny: None. S.E. Judd: None. N. Zakai: None. M. Cushman: None.
- © 2014 by American Heart Association, Inc.