Abstract 19594: Intra-Hepatic Fat Assessed on Cardiac CT Examinations Is Associated With Arterial Stiffness in a High Risk Population Independent of the Cardiometabolic Risks: The Baptist Employee Healthy Heart Study
Introduction: Hepatic fat a measure of visceral adiposity is evolving as a significant risk factor for cardiovascular disease (CVD). Arterial stiffness (AS) is one of the markers of subclinical CVD, often measured by the augmentation index (AIx). In this study we evaluated if individuals with higher burden of intra-hepatic adiposity are at higher risk of arterial stiffness among a high metabolic risk population free of known CVD.
Methodology: The Baptist Employee Healthy Heart Study (BEHHS) is an ongoing lifestyle intervention study examining the effects of web-based interventions on reducing CVD risk in individuals with metabolic syndrome and type II diabetes mellitus. Participants had their brachial arterial AIx, assessed using the EndoPAT 2000 device (Itamar Medical, Israel). Participants older than 35 years old had CT scans done for coronary calcium. Hepatic and splenic attenuation values were measured using regions of interest (ROI) greater than 100 mm2 in area. A Liver: spleen attenuation ratio (LSR)<1.0 was considered positive for significant intra-hepatic fat.
Results: Results: The population consisted of 141 participants, 74% women, 49% Hispanic, with a mean age of 52 ± 9 years. Overall 71 (50%) of the participants had significant intra-hepatic fat; LSR<1.0. The mean AIx for LSR<1.0 was 17.7 ± 18.7 and for individuals with LSR≥ 1.0, AIx 9.9 ± 14.3, p value=0.01. Individuals with LSR< 1.0 were more likely to be in the highest AIx quartile (figure 1). The presence of intra-hepatic fat was associated with greater odds of being in the higher quartiles of the AIx in a multivariate ordered logistic regression analysis, see table 1.
Conclusion: In this study of high risk individuals, the presence of significant intra-hepatic fat was associated with arterial stiffness independent of the cardiometabolic risks. Although further studies are necessary to understand the relationship, the above finding has implication for clinical practice and population health.
Author Disclosures: E.T. Oni: None. E.C. Aneni: None. G. Nagi: None. E. Veledar: None. L. Roberson: None. S. Shaharyar: None. O. Jamal: None. S.S. Ali: None. H. Guzman: None. R. Malik: None. M. Aziz: None. R. Cury: None. J. Fialkow: None. A.S. Agatston: None. J. Post: None. T. Feldman: None. K. Nasir: None.
- © 2014 by American Heart Association, Inc.