Abstract 19379: The Relationship Between Dietary Magnesium Intake and Heart Failure Hospitalizations in African American Adults: The Jackson Heart Study
Background: Low serum and dietary magnesium (Mg) intake are established risk factors for stroke, coronary disease, hypertension and type 2 diabetes mellitus, but little is known on the relationship between Mg intake and heart failure (HF). African Americans are known to have a low dietary Mg intake and have a high risk of HF compared to the general population; thus, an ideal group to study this relationship. We hypothesize that dietary Mg relates to HF hospitalization in African Americans.
Methods: A cohort study was conducted on 5,133 participants from Jackson Heart Study, recruited during 2000-2004, in Jackson (MS), who completed a 61-item semi-quantitative food frequency questionnaire. The main outcome was hospitalization for HF during 2005-2010. We related different cutoffs of dietary Mg intake (overall, mean, Recommended Daily Allowance [RDA] for men and RDA for women) with HF hospitalization using Cox proportional hazards modeling adjusting for potential confounding. Since HF hospitalization risk may vary by systolic function, we also conducted subgroup analyses by ejection fraction. Given gender differences in RDA cutoffs for Mg intake, we also tested for interaction by gender.
Results: The study cohort had a mean age of 55.3 (SD 12.8 yrs), of which 63.4% were women, 21.6% had diabetes, 62.7% hypertension, and 10.6% had coronary or cerebrovascular disease. Cox modeling showed Mg Intake above mean (308mg/day) or RDA levels for women (310mg/day) to be related to decreased hazards of HF hospitalization, adjusted Hazard Ratio 0.51 (95% CI 0.30-0.85) and 0.49 (95% CI 0.29-0.83), respectively; but only in subjects with ejection fraction (EF) ≤55% (Table). Test for interaction by gender was not significant.
Conclusions: Dietary Mg intake was related to HF hospitalization only in African Americans with EF ≤55%. Further studies exploring the mechanisms that underlie this relationship may be warranted.
Author Disclosures: T.H. Taveira: None. D. Ouellette: None. A. Gulum: None. G. Choudhary: None. C.B. Eaton: None. W.H. Wu: None.
- © 2014 by American Heart Association, Inc.