Abstract 19127: Gamma glutamyltransferase and Risk of Incident Heart Failure
Background: The relationship between gamma glutamyltransferase (GGT) and incident heart failure (HF) has not been reliably quantified.
Methods and Results: We assessed the association between GGT and HF risk in a population-based cohort of 1,797 men aged 42-61 years free from HF at baseline. Additionally, we performed a meta-analysis of relevant prospective studies identified from MEDLINE, EMABSE, and Web of Science databases. During a mean follow-up of 20.4 years, 155 participants developed HF (4.2 cases per 1000 person-years). Loge GGT levels was approximately log-linearly associated with HF risk. The age adjusted hazard ratio (HR) for HF per 1 standard deviation (SD) higher baseline GGT levels was 1.66 (95% confidence interval [CI] 1.43-1.94). This association persisted after adjusting for established HF risk factors 1.48 (95% CI:1.24, 1.76).These findings remained consistent in analyses accounting for incident coronary heart disease events, excluding individuals with prior cardiovascular events, and in subgroups defined by several individual participant characteristics. In pooled random effects meta-analysis of five population-based studies (210,858 participants and 1,754 HF events), the HR for HF per 1 SD higher baseline GGT level was 1.30 (95% CI: 1.23-1.38) with no evidence of heterogeneity between contributing studies.
Conclusions: There is a positive log-linear association between GGT and risk of incident HF, which is independent of established risk factors. Further research is needed to assess any causal relevance to the association.
Figure 1 Cumulative hazard curves for incident heart failure by quartiles of GGT
The median GGT level (IU/L) was 12.0 (range 8-13) for the lowest quartile; 17.0 (range 15-19) for the second quartile; 24.5 (range 21-27) for the third quartile; and 43.0 (range 31-56) for the top quartile
Figure 2 Hazard ratios for heart failure by quartiles of baseline GGT levels
Hazard ratios (HR) were calculated in reference to the first quartile of GGT, and plotted against the geometric mean GGT within each category. 95% CIs were calculated from floating variances (including the reference group).
Author Disclosures: S.K. Kunutsor: None. J. Kauhanen: None. J. Butler: None. J.A. Laukkanen: None. H. Khan: None.
- © 2014 by American Heart Association, Inc.