Abstract 19064: Association of Diagonal Earlobe Crease With Traditional Cardiovascular Risk Factors and Coronary Artery Calcification in the General Population: Heinz Nixdorf Recall Study
Objective: A link of the presence of diagonal earlobe crease (DEC) and cardiovascular disease is suggested in the literature. We aimed to determine the association of DEC with traditional cardiovascular risk factors and coronary artery calcification (CAC) in the general population.
Methods: Participants from the population based Heinz Nixdorf Recall Study (50-80 years), participating in the 2nd examination, were included. Presence of DEC was determined from pictures taken of both ears. Unadjusted and multivariable adjusted logistic regression analysis was used to determine the association of DEC with cardiovascular risk factors including age, gender, body mass index (BMI), systolic blood pressure, total- and HDL-cholesterol, diabetes, antihypertensive and lipid lowering medication, as well as current smoking. For association with CAC (as log[CAC+1]), unadjusted and risk factor adjusted linear regression analysis was performed.
Results: From 3359 subjects (64 ± 7.6 years, 49.5 % male) included, 578 (17.2%) subjects had a DEC of at least one ear. Participants with DEC were older (67± 7.1 vs. 64 ± 7.5, p<0.0001), more often male (60 vs. 47%, p<0.0001), had a higher BMI (29± 4.1 vs. 28± 4.6 kg/m2, p<0.0001) and systolic blood pressure (137± 20 vs. 134± 20 mmHg, p<0.0001), lower total- (222± 41 vs. 226± 41 mg/dl, p=0.026) and HDL-cholesterol (57± 15 vs. 61± 17 mg/dl, p<0.0001), had more frequent diabetes (26 vs. 17%, p<0.0001), and were more frequent on lipid lowering (29 vs. 22%, p<0.0001) and antihypertensive medication (56 vs. 47%, p<0.0001). In multivariable regression analysis, only age (1.068 (1.053-1082), p<0.0001), male gender (1.619 (1.310-2), p<0.0001), and BMI (1.058 (1.038-1.082), p<0.0001) were independently associated with presence of DEC. In unadjusted analysis, presence of DEC was associated with higher CAC-score (0.882 (0.640-1.124), p<0.0001). This effect was no longer present when controlling for risk factors (0.029 (-0.170 - 0.228), p=0.8).
Conclusion: In the general population, DEC is associated with higher risk factor profile and higher CAC-score, mainly explained by age, gender, and BMI. Our results suggest that DEC may serve as an excellent clinical marker of cardiovascular risk, however, not as an independent risk factor.
Author Disclosures: M. Kaynar: None. A.A. Mahabadi: None. S. Moebus: None. H. Kälsch: None. N. Pundt: None. N. Lehmann: None. K. Jöckel: None. R. Erbel: None.
- © 2014 by American Heart Association, Inc.