Abstract 18730: Effects of Maternal Prenatal Psychosocial Stress on Early Childhood Hemodynamic Responses: A Chinese Experience
Introduction: Prenatal psychosocial stress (PPS) manifesting, as anxiety (PA) and/or depression (PD), is common during human pregnancy. There are few studies in humans on long-term consequences of such stress on offspring, particularly for the cardiovascular system.
Hypothesis: Maternal PPS in pregnancy altered the stress response of healthy full-term offspring during early childhood.
Methods: 216 Chinese pregnant women (71, 72 and 73 during the first, second and third trimesters, respectively) underwent validated structured questionnaire-based PPS and serum cortisol level assessments. Offspring, were subjected to a 10-minute-video stress challenge at ages 7-9 years; resting and post-stress heart rate (rHR,sHR )and blood pressure (rBP, sBP) were measured.
Results: The children of mothers who had experienced PPS, particularly anxiety, exhibited greater stress hemodynamic responses independently of child gender or pregnant trimesters (Table1 ).
There were significant bivariate correlations between maternal cortisol and children’s resting and stress hemodynamic parameters (all P<0.01) particularly for the group with PPS (all P<0.01 except for rDBP in PPS group; only rHR and sHR in non-PPS group, both P<0.01).
Multiple regression analyses were undertaken, separately for each trimester, with children’s hemodynamic responses as the dependent variable and including levels of PA and PD (absent, mild, moderate and severe), maternal cortisol and gender as independent variables. Effects of PA were more consistent (all P<0.05 except for rHR, sHR in all trimesters and sDBP in trimester 1 and 3) Effects of maternal cortisol were limited to ΔSBP in trimester 2.
Conclusion: The results suggest a long-term influence of PA on the cardiovascular response to stress of their offspring, which might contribute to later development of cardiovascular disease later as has been documented for other prenatal influences.
Author Disclosures: F. Fan: None. Y. Zou: None. H. Tian: None. Y. Zhang: None. J. Zhang: None. X. Ma: None. Y. Liu: None. Y. Meng: None. Y. Yue: None. K. Liu: None. A. Dart: None.
- © 2014 by American Heart Association, Inc.