Abstract 18697: “Forgotten” Cluster with Moderately-impaired LV Diastolic Function Determined by Doppler Echocardiography
Background: Left ventricular (LV) diastolic function is mainly determined by the waves of transmitral flow and mitral annular velocity and classified as normal diastolic function, or mild, moderate, and severe diastolic dysfunction. However, it has been known that some subjects are not assigned to any group by the criteria. We investigated the prevalence and severity of the undetermined subjects in the general population.
Methods: We studied 1559 community-dwelling subjects without obvious heart diseases or signs of heart failure (mean age, 61±12 years; 576 men, 983 women) who participated in the annual health checkup in a rural Japanese community, Arita-cho. LV diastolic dysfunction was determined with the waves of transmitral flow and mitral annular velocity, using established criteria (Redfield MM, JAMA2003). We investigated the plasma BNP levels in the predetermined and undetermined groups of LV diastolic dysfunction.
Results: In this population, 769 subjects (49%) had normal LV diastolic function; 328 (21%), 188 (12%) and 9 (0.9%) had mild, moderate and severe diastolic dysfunction, respectively. Importantly, 265 subjects (17%) were not assigned to any group: 135 subjects with E/A ratio >1.5 and E/e’ <10 (“Super-normal”) and 130 subjects with E/A ratio 10 (“Moderate-plus”). Subjects with Super-normal had the lowest BNP levels. Interestingly, BNP levels of subjects with Moderate-plus were comparable to those with moderate dysfunction, even though they indicated the impaired relaxation pattern of transmitral flow.
Conclusions: In the community-based population, one sixth of subjects were not assigned to any predetermined group of LV diastolic dysfunction. It is noteworthy that the undetermined group includes the subjects equal to the moderate diastolic dysfunction, even though they appear to have mild diastolic dysfunction if assessed solely by the transmitral flow pattern.
Author Disclosures: T. Hasegawa: None. M. Asakura: None. H. Kanzaki: None. H. Asanuma: None. A. Funada: None. T. Ohara: None. Y. Sugano: None. S. Yasuda: None. H. Ogawa: None. T. Anzai: None. M. Kitakaze: None.
- © 2014 by American Heart Association, Inc.