Abstract 18608: Ventricular Myocarditis Coincides With Atrial Myocarditis in Patients
Introduction: Studies on the role of inflammatory cells in myocarditis focus mainly on the ventricles. However, little is known about inflammatory cell infiltration of the atria in patients with diagnosed myocarditis. A common complication in myocarditis is atrial fibrillation (AF), which is associated with inflammation of the atria. Therefore, we quantified inflammatory cells both in the ventricles and the atria of patients with lymphocytic myocarditis and catecholamine myocarditis.
Methods: From post-mortem obtained hearts of lymphocytic myocarditis patients (n=5), catecholamine myocarditis patients (n=5) and control patients (n=5), tissue slides of the left and right ventricles and left and right atria were stained with antibodies identifying neutrophils, lymphocytes and macrophages. These cells were subsequently quantified in atrial and ventricular myocardium and in the atrial adipose tissue.
Results: The number of macrophages were significantly increased in the myocardium of the atria and the ventricles of both lymphocytic myocarditis and catecholamine myocarditis patients. Neutrophils and lymphocytes were also increased, albeit to a lesser extent. Additionally, all three inflammatory cells were increased to a varying extent in adipose tissue of the atria in both myocarditis patient groups. Neutrophils correlated strongly between the atrial and ventricular myocardium of catecholamine myocarditis patients, whereas macrophages correlated strongly for both forms of myocarditis. Between the adipose tissue and myocardium of the left atria, strong and significant correlations were for macrophages in lymphocytic myocarditis patients and neutrophils in catecholamine myocarditis patients.
Conclusions: These data show that in patients with lymphocytic and catecholamine myocarditis inflammatory cells infiltrate not only the ventricles but also the atria and may suggest a predisposition towards the development of AF.
Author Disclosures: P. Krijnen: None. M. Begieneman: None. L. Rijvers: None. B. Kubat: None. W. Paulus: None. L. Roozendaal: None. A. Van Rossum: None. H. Niessen: None.
- © 2014 by American Heart Association, Inc.