Abstract 18588: Lipoprotein Sub-fractions by Ion Mobility Analysis Association with Burden of Subclinical Coronary Atherosclerosis in a High Risk Population: the Baptist Employee Healthy Heart Study (BEHHS)
Introduction: Plasma LDL-c, HDL-c and triglycerides are traditionally used to assess dyslipidemic burden and subsequent cardiovascular disease (CVD) risk management. In this study we whether detailed assessment across spectrum of multiple lipoproteins subclasses, distinguished by their physiochemical properties, can guide atherosclerotic risk assessment as measured by coronary artery calcification (CAC) burden in a high CVD risk population.
Methods: The Baptist Employee Healthy Heart Study (BEHHS) is an ongoing lifestyle intervention study examining the effects of web-based interventions on reducing CVD risk in individuals with metabolic syndrome (MS) and type II DM. Cardio IQ™ Ion Mobility lipoprotein fractionation was utilized for advanced lipid subclass measurement resulting direct quantification of particles in each lipoprotein subclass fraction.
Results: The population consisted of 171 participants (74% women, 49% Hispanic, mean age: 52 ± 9 years) undergoing CAC testing. The table demonstrates a significant trend of a lower LDL particle size concentration with increasing CAC score. Conversely, those with CAC=0 were more likely to have higher concentration of large LDL, small IDL, small & large HDL respectively. In our study 104 (60%) had LDL pattern B (LDL Peak Size < 218.1) and more likely to have a higher prevalence of CAC vs those without it (23% vs 12%, p=0.06). In multivariate adjusted ordinal logistic regression (accounting for RF’s and non HDL-C), LDL pattern B was associated with 2.0 fold (95% CI: 1.0-3.9) risk of higher CAC category, the respective OR among those 54% individuals LDL<130 mg/dl was 3.2 (95% CI: 1.2-8.5).
Conclusions: Several lipoprotein subclasses by ion mobility analysis, particularly smaller LDL peak particle diameter (LDL pattern B) were related to increased burden of coronary atherosclerosis independent of standard lipoprotein analysis in high risk individuals with MS/DM.
Author Disclosures: E. Aneni: None. E. Veledar: None. E. Oni: None. L.L. Roberson: None. J. Post: None. G. Nagi: None. S. Shaharyar: None. O. Jamal: None. S.S. Ali: None. R. Malik: None. M. Aziz: None. A. Younus: None. B. Rosell: None. H. Guzman: None. R. Cury: None. M. Ozner: None. J. Fialkow: None. T. Feldman: None. A.S. Agatston: None. K. Nasir: None.
- © 2014 by American Heart Association, Inc.