Abstract 18300: Reduction in Blood Pressure with Weight-loss Intervention in Overweight and Obese Patients with Heart Failure
Background: Reductions in blood pressure (BP) have been reported with energy restriction and weight loss; however, the effect of a behavioral weight management intervention on BP in overweight and obese patients with heart failure (HF) and type 2 diabetes mellitus (DM) has not been studied.
Objectives: To describe weight and BP changes over time and identify predictors of BP reduction in a cohort of overweight and obese patients with HF and DM enrolled in a weight loss intervention.
Methods: Patients were recruited to participate in a 3-month intensive behavioral weight management intervention and received one of two standard structured energy-restricted meal plans (1200 or 1500 kcal/day) based on their computed calorie deficit. Weight and BP patterns were observed and recorded at baseline and each follow-up visit - 2, 4, 8, and 12 weeks - with a registered dietician.
Results: Forty five patients - mean age 59.84 ± 9.96 ; weight 238.8 ± 45.2 pounds; systolic BP 125.5 ± 19.7 mmHg, diastolic BP 74.6 ± 11.0 mmHg; 47.9% White; 16.4% Hispanics; 12.3 % Blacks; 4.1% Asians - participated in the study and completed the 3-month intervention. At 3 months, participants lost an average of 8.79 pounds (p=0.000); systolic and diastolic BP decreased by 10.11 and 5.56 mmHg, (p= 0.000 and 0.002), respectively (see graph). Weight reduction accounted for 27% and 37% of the variance in systolic and diastolic BP reductions at 3 months, respectively while controlling for age, gender, race, baseline weight, and presence or absence of diabetes or hypertension at baseline.
Conclusion: Our findings elucidate the importance of weight loss in producing a hypotensive effect in overweight or obese patients with HF and DM which is vital given that hypertension is often indicated in health complications in this vulnerable population. Strategies to optimize behavioral weight management interventions as potential key to reducing BP and sustaining BP reductions warrants further investigation.
Author Disclosures: M. Motie: None. L.S. Evangelista: None.
- © 2014 by American Heart Association, Inc.