Abstract 18191: Atrial Fibrillation: Possible Risk Factor of Senile Pulmonary Fibrosis?
Introduction: Idiopathic Pulmonary Fibrosis (IPF), usually occurred in the aged. Some possible risk factors are associated with IPF, like gastroesophageal reflux. However, there is hardly a complete explanation of the pathophysiological mechanisms of IPF, presenting some unrecognized risk factors could help studying the pathogenesis of IPF.
Hypothesis: Chronic thromboembolic pulmonary hypertension patients share the same Image features and clinical manifestations of advanced secondary pulmonary changes with those of IPF patients. Chronic thromboembolic pulmonary hypertension patients with similar secondary pulmonary changes and without clear thrombus are easily misdiagnosed as IPF . Studies have shown that right ventricular thrombosis resulted from atrial fibrillation is one of the causes of chronic recurrent pulmonary embolism, We assessed the hypothesis that atrial fibrillation be associated with Senile IPF.
Methods: Selected IPF patients aged ≥65 years old . 43 of them are without related risk factors. Other 43 IPFpatients are with the related risk factors,43 patients (Control group), without pulmonary fibrosis or related risk factors. We recorded the time of atrial fibrillation’s first happening, seizure frequency, and D-dimer levels when atrial fibrillation occurring,and the use of anticoagulant medication, the range of pulmonary fibrosis by high-resolution CT, and analysized the correlation between those and the range of pulmonary fibrosis .
Results: Comparing the incidence and duration of first diagnosed of atrial fibrillation, there was a significant statistical difference between the IPFpatients without known risk factors and those with known related risk factors, or the control group (all P<0.0001). the range of pulmonary fibrosis of IPF patients was correlated with happening of atrial fibrillation, frequency of increased D-dimer levels positively, and used of anticoagulant medication negatively.
Conclusion: In conclusion, atrial fibrillation can be considered one possible risk factor for senile IPF, and chronic pulmonary embolism may be atrial fibrillation’s pathological pathway leading towards IPF. Antithrombotic therapy should be used among the aged patients who suffer atrial fibrillation and pulmonary fibrosis.
Author Disclosures: C. Wu: None. Y. Guo: None.
- © 2014 by American Heart Association, Inc.