Abstract 18163: Clinical Cardiovascular Risk During Young Adulthood in Offspring of Hypertensive Pregnancies
Introduction: Offspring of hypertensive pregnancies have increased cardiovascular risk factors during childhood. We studied whether pregnancy hypertension is associated with clinically relevant changes in the cardiovascular risk profile in adults at 20 years of age.
Methods: We used data on 2868 offspring of women enrolled during pregnancy into the Western Australia Pregnancy Cohort (Raine) Study with detailed information on pregnancy as well as prospective measures into adult life of cardiovascular risk factors on 1151 subjects, including body size, blood pressure and fasting glucose, insulin and lipids.
Results: Adult offspring of hypertensive pregnancies were 2.5 times (95% CI 1.32 to 4.56, p =0.004) more likely to have lifetime QRisk scores above the 75th centile with, on average, a 3.7+/-0.97 mmHg (p<0.001) higher systolic blood pressure and 1.1+/-0.5 kg/m2 (p=0.04) increase in body mass index. 30% of those who were clinically hypertensive at age 20 had been born to mothers with hypertension in pregnancy. Preeclampsia or hypertension resulting in preterm birth was associated with a 5.4+/-1.97 mmHg (p=0.007) increase in blood pressure and a 3-fold (95%CI 1.3 to 7.0, p =0.01) greater risk of being hypertensive, without differences in BMI. Pregnancy-induced hypertension associated with a smaller 3.2+/-0.99mmHg blood pressure rise (p=0.001) without increased risk of clinically apparent hypertension and a 2-fold (95%CI 1.5to 2.8, p=0.001) increased risk of being obese or overweight. Associations were consistent throughout early life and independent of other birth-factors.
Conclusions: Maternal hypertension in pregnancy was associated with increased blood pressure such that 30% of adults aged 20 years with hypertensive blood pressures were born to a hypertensive mother. Incidence of hypertension was higher if their mother had a more complicated pregnancy history. Raised blood pressure and BMI were evident throughout childhood and early intervention may be of value to prevent adult hypertension.
Author Disclosures: E.F. Davis: None. A.J. Lewandowski: None. C. Aye: None. W. Williamson: None. H. Broadman: None. R. Huang: None. T.A. Mori: None. J. Newnham: None. L. Beilin: None. P. Leeson: None.
- © 2014 by American Heart Association, Inc.