Abstract 18104: Chagas Disease is not Independently Associated with Atrial Fibrillation in Patients with Cardiomyopathy
Introduction: Chagas Disease (CD) has been associated with an increased incidence of stroke, which may ultimately be due to an increased prevalence of atrial fibrillation (AF). Observational studies support this possibility, but data is conflicting. Furthermore, it is unknown if CD represents an independent risk factor for AF when compared to other cardiomyopathies.
Hypothesis: CD is significantly associated with an increased prevalence of AF when compared to other cardiomyopathies.
Methods: PubMed, EMBASE, Cochrane Central and Latin American databases were searched for studies that directly compared the prevalence of AF in CD patients to a non-CD group. Odds-ratios were computed using a random-effects model due to anticipated heterogeneity. Subanalyses were performed on studies in which both the control group and CD patients had (1) cardiomyopathy and (2) heart failure.
Results: A total of 18 studies and 10,724 patients were included, of whom 4,216 (39.3%) had a positive serology for CD. In the pooled data, AF was significantly more prevalent among the CD group (OR 1.69; 95% CI 1.24-2.30; p<0.001; Figure 1). However, no significant difference was observed between groups when the analysis included only patients with cardiomyopathy (11 studies; OR 1.33; 95% CI 0.94-1.89; p=0.11; Figure 2A) and heart failure (6 studies; OR 1.03; 95% CI 0.75-1.43; p=0.85; Figure 2B).
Conclusions: Our meta-analysis suggests that in patients with cardiomyopathy or heart failure, Chagas Disease etiology is not independently associated with atrial fibrillation.
Author Disclosures: R.N. Cardoso: None. D. Garcia: None. G. Fernandes: None. F. Macedo: None. M. Ansari: None. R.D. Mitrani: None.
- © 2014 by American Heart Association, Inc.