Abstract 18078: Strain rather than Diastolic Parameters correlates with Heart Failure Risk Factors
Background: Stage B heart failure (SBHF) is currently defined by structural heart disease (previous MI, LV remodelling, hypertrophy and low EF). The roles of functional measures (global longitudinal strain [GLS] and diastolic dysfunction [DD]) as markers of SBHF are undefined.
Method: Pts >65 yo with ≥1 HF risks (hypertension, type 2 diabetes, obesity, previous chemotherapy, F/H of HF or previous cardiac history) were recruited from the local community. All subjects underwent questionnaires, 6-minute walk (6MW) and echocardiography. Abnormal echo was defined by GLS (-18%), LV mass index (LVMI) (95 for female, 115 for male, g/m2), 6MW (455 meters), E/e’ (12, medial), DecT (<140 or >240 ms) and LAVI (≥32 ml/m2).
Results: Of 236 pts (age 71±5, 47% men), 22% had one, 42% had two and 36% had >2 listed HF risk factors. There were significant associations of #HF risks with reduced GLS (p=0.008 for trend), increased LVMI (p=0.002) and shorter 6MW (p=0.004). There were no significant associations with diastology measurements, including increased mitral annular E/e’ (p=0.67), deceleration time (p=0.61) and mitral E/A (p=0.46) (Table). The relative risk of abnormal GLS in those with more than one risk is 1.38 (95%CI 1.05-1.81; p=0.019), increased LVMI 1.31 (1.00-1.74; p=0.055), shorter 6MW 1.22 (0.99-1.49; p=0.059).
Conclusion: In asymptomatic pts with HF risks, GLS (but not DD) showed an association with number of risks, similar to LVMI and 6MW distance.
Author Disclosures: H. Yang: Research Grant; Modest; HY is supported by a Health Professional Scholarship from the National Heart Foundation of Australia (100307). K. Negishi: None. M. Nolan: None. Y. Wang: None. L. Wright: None. T. Marwick: None.
- © 2014 by American Heart Association, Inc.