Abstract 17862: Efficacy and Optimal Duration of Heart Failure Medications in Preventing the Recurrence of Stress-induced Cardiomyopathy
Introduction: stress-induced cardiomyopathy(SCMP) is a rapidly reversible form of acute heart failure.However, the data on efficacy of prolonged heart failure(HF) medications are scanty.We therefore aimed to evaluate whether HF medications can prevent the recurrence of SCMP and how long period of treatment is optimal.
Hypothesis: prolonged heart failure medications can prevent the recurrence of SCMP.
Method: From May 2008 to December 2013, the clinical data of 41 patients who had recovered from SCMP in tertiary referral hospital were reviewed.The patients were grouped into two levels(No recurrence vs Recurrence)(table 1) to determine efficacy of HF medications.A diagnosis of SCMP is based on Mayo Clinic criteria and HF medications included renin-angiotensin system blockers or beta blockers.
Results: over mean follow-up of 1.2 ± 1.47 years, 9 patients(21%) experienced second episode of SCMP but 33 patients(79%) did not suffer from recurrence of SCMP.3 patients(33%) of SCMP recurrence group received HF medications and 24 patients(73%) of no recurrence group received HF medications.On multivariate analysis, only HF medication use was associated with SCMP recurrence(the odds ratio was 0.19 and the 95% confidence interval was 0.04~0.91).Kaplan-Meier curves showed that patients with HF medications were at decreased risk of SCMP recurrence(Figure A) and most of recurrence occurred within 132 days after first episode of SCMP (Figure B).
Conclusion: Our data shows clinical evidence of chronic HF medications use for at least 5 months in patients with SCMP, even though they were recovered, in order to prevent the recurrence of SCMP.
Author Disclosures: T. Kim: None. M. Kim: None. J. Kim: None. J. Song: None. S. Park: None. S. Park: None.
- © 2014 by American Heart Association, Inc.