Abstract 17857: Clinical Outcomes in Patients with Takayasu’s Arteritis: Retrospective Analysis From National Inpatient Sample Database
Background: Takayasu’s arteritis (TA) is an inflammatory condition of unknown etiology involving large cardiac vessels, predominantly the aorta and its major branches.. We aimed to determine the cardiac manifestations and predictors of mortality in patients with TA in the United States.
Methods: All patients (≥ 18 years) diagnosed with TA in the Nationwide Inpatient Sample (NIS) 2009 - 2010 database using the International Classification of Diseases 9th revision (ICD 9 code 446.7) were included in the analysis. We analyzed demographics, traditional risk factors, cardiac manifestations and predictors of mortality in patients with TA.
Results: TA constituted 0.003% (n=1,411) of all in-hospital admissions. The mean age was 51 years, 78.6% were women, 66.46% whites and only 3.3% were Asian. Traditional risk factors prevalent in our study were hypertension (61.5%), hyperlipidemia (26.2%), diabetes (23%), smoking (18.6%), and obesity (9.8%) with no significant difference between men and women (except dyslipidemia p<0.001). Prevalence of coronary artery disease (CAD), heart failure and acute myocardial infarction (AMI) was 29.9%, 19.38% and 11.45% respectively. Atrial fibrillation/atrial flutter was seen in 10% of our study population. In-hospital mortality was 5.9% (Asians 30%, whites 7%, blacks 4% and hispanics 3%), and 13.6% in patients with AMI. In multimodel regression analysis, age (OR 1.03, p=0.03) and Asian origin (OR 6.39, p=0.03) were found to be independent predictors of mortality. Interestingly, age was also found to be an independent predictor for both atrial fibrillation/atrial flutter (OR 1.07, p=0.001) and CAD (OR 1.03, p=0.002) in adjusted analysis.
Conclusion: In the largest study of US population, we reported prevalence of various risk factors and cardiac manifestations of TA. AMI was major cause of death in patients with TA, while Asian origin was independent predictor of mortality.
Author Disclosures: J. Garg: None. P. Krishnamoorthy: None. C. Palaniswamy: None. A. Sharma: None. D. Jain: None. S. Goel: None. H. Ahmad: None. G. Lanier: None.
- © 2014 by American Heart Association, Inc.