Abstract 17837: The Correlation Between Complex Fractionated Atrial Electrogram and High Sensitivity-C Reactive Protein
Introduction: Although complex fractionated atrial electrogram (CFAE) is purported to represent critical site for atrial fibrillation (AF) perpetuation, the mechanism and the significance of CFAE in the genesis of AF remain poorly understood. We investigated relationship between CFAE area and serum level of high-sensitivity C-reactive protein (hs-CRP).
Hypothesis: CFAE area is correlated with serum level of hs-CRP in patients with AF.
Methods: Consecutive 25 patients (20 men, 5 women, mean age 57±10 years) with drug resistant AF underwent first ganglionated plexi (GP) ablation were enrolled. Immediately before radiofrequency energy applications, blood sampling was obtained from systemic circulation. Three dimensional electroanatomical mapping of CFAE during AF was performed at least 100 points in the whole left atrium (LA). CFAE mapping was performed twice in all patients before and after GP ablation if AF was sustained.
Results: CFAE area was estimated in all patients before GP ablation and in 17 patients after GP ablation. CFAE area was decreased after GP ablation (from 10.7±8.6% to 10.2±6.1%). Among 25 patients, positive hs-CRP (≥0.017 mg/dL) was observed in 16 patients and negative (<0.017 mg/dL) in 9 patients. Clinical characteristics were not significantly different between two groups. CFAE area before GP ablation was significantly larger in patients with positive hs-CRP than in those with negative hs-CRP (13.2±9.0% vs. 6.2±5.8%, p=0.04; Figure 1). Serum level of hs-CRP was significantly correlated with CFAE area before GP ablation (r=0.51, p=0.009; Figure 2), but not after GP ablation (r=0.19, p=0.47). Multivariate analysis revealed that only hs-CRP level was significantly related to CFAE area before GP ablation (β=0.39, p=0.044).
Conclusions: Serum level of hs-CRP was correlate with CFAE area before GP ablation in patients with AF. Latent inflammation may contribute to CFAE formation.
Author Disclosures: D. Ishigaki: None. T. Arimoto: None. T. Iwayama: None. N. Hashimoto: None. Y. Kumagai: None. S. Nishiyama: None. H. Takahashi: None. T. Shishido: None. T. Miyamoto: None. J. Nitobe: None. H. Aoyama: None. T. Watanabe: None. I. Kubota: None.
- © 2014 by American Heart Association, Inc.