Abstract 17695: Femoral Artery Distensibility and Intima Media Thickness (IMT), but Not the Ankle Brachial Index, Are Associated With Measures of Physical Function: The San Diego Population Study (SDPS)
Background: Lower extremity peripheral artery disease (PAD), even when asymptomatic, is associated with decreased functional status and mobility. The ankle brachial index (ABI), the standard for PAD diagnosis, may not decrease significantly until substantial lower extremity obstructive disease exists, and when apparent declines in physical function may already be present. Thus, we examined the association of measures of femoral artery atherosclerosis and distensibility, which may be better earlier indicators of pre-clinical lower extremity disease, with measures of physical function.
Methods: The SDPS includes 1103 non-Hispanic white, African-American, Hispanic and Asian men and women, average age 70, who participated in a clinic exam between 2007-11. Initial data read from ultrasound images of the superficial and common femoral arteries from the 2007-11 exam is currently available on 295 of 1103 participants. Linear regression was used to assess the associations of femoral artery IMT, distensibility, and the normal range ABI (0.91-1.4) with measures of physical function, including the summary performance score (SPS) and the SF-36 physical component score (PCS).
Results: In models adjusted for demographics, lifestyle factors, comorbidities, blood pressure, kidney function, and inflammation/coagulation, each mm higher of the superficial femoral artery IMT was significantly associated with a 2.22 lower SPS (95% CI (-4.05, -0.40), p=0.017). Each 1% greater cross-sectional distensibility of the common femoral artery was significantly associated with lower SF-36 PCS (-0.15 (-0.28, -0.02), p=0.026). Common and superficial femoral IMT were not associated with the PCS (p=0.80, 0.84), and cross-sectional distensibility was not associated with the SPS, p=0.30. The ABI was not associated with either the SPS (p=0.26) or the SF-36 PCS (p=0.81).
Conclusions: In this healthy, diverse population of older adults, superficial femoral artery IMT and cross-sectional distensibility, but not the ABI in the normal range, appear to be associated with early changes in the SPS and SF-36 PCS. These subclinical femoral artery measures may be better indicators than the ABI for detecting pre-clinical lower extremity PAD and early changes in functional status.
Author Disclosures: C.L. Wassel: None. M.A. Allison: None. E.J. Barinas-Mitchell: None. J.H. Ix: None. N.S. Jenny: None. J.O. Denenberg: None. D.E. Rifkin: None. B.J. McQuaide: None. A. Marasco: None. M.H. Criqui: None.
- © 2014 by American Heart Association, Inc.