Abstract 17536: Association Between Chronic Obstructive Pulmonary Disease and Risk of Coronary Vasospastic Angina: a National Database Study
Background: Although chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease, little is known about the relation of COPD to coronary vasospastic angina (CVsA)
Methods: The case-control study applied a longitudinal health insurance database (LHID) from the National Health Insurance program. LHID was a retrospective cohort as a population of 1,073,891 and randomly sampled from the entire population of 22,717,053 that were from 1996 to 2008. Patients who had at least one admission claim with an International Classification of Diseases Ninth Revision, Clinical Modification (ICD-9-CM) code of 4131 were identified as CVsA. The control group I was established by identifying other ischemic heart disease )ICD-9-CM codes 410 to 414 except 4131). The remaining subjects with matched age, gender and entry year from the LHID were defined as the control group II. Multivariate logistic regression analyses were performed and simultaneously adjusted for potential confounders to evaluate the association of COPD with CVsA.
Results: We found 697 patients if CVsA (prevalence = 69.7/100,000 persons), and the mean age was 55 years old, male to female was 0.97:1. There were 115,433 and 2,788 patients in the group I and II, respectively. Compared with other ischemic heart disease group, CVsA patients were more likely to have prior COPD [adjusted odds ratio (OR) = 2.13, 95% confidence interval (CI) = 1.65 - 2.73], had more COPD hospitalization frequency (>= 3 times in 1 year) (adjusted OR = 5.25, 95% CI = 1.93 - 14.29), be younger and had hyperlipidemia (adjusted OR = 1.82, 95% CI = 1.54 - 2.14), even after adjusting for the confounders and co-morbidities.
Conclusions: COPD was independently associated with a higher incidence of CVsA. Endothelial dysfunction and low-grade inflammation might play a role on CVsA.
Author Disclosures: M. Hung: None. M. Hung: None. S. Chiang: None. L. Wang: None. N. Chang: None. H. Lin: None.
- © 2014 by American Heart Association, Inc.