Abstract 17527: Partitioning Echocardiographic Size and Function Parameters of the Right Ventricle Using CMR Normative Values from the MESA Study
Introduction: Right ventricular (RV) size and function are important predictors of outcomes. There are, however, no cut-off values for degrees of RV enlargement or dysfunction. Recent guidelines on the right heart classify measurements only as abnormal or normal. In a cohort of patients with closely-spaced 2DE and cardiovascular magnetic resonance (CMR) we sought to determine magnitudes of abnormality in 2DE values by using CMR normative values as determined by the Multi-Ethnic Study of Atherosclerosis (MESA) study.
Methods: We studied 217 patients, who had CMR (1.5T), and 2DE within 2±2.5 d. CMR RV ejection fraction (EF) and end-diastolic volume (EDV) were measured using the method of disks. The RV-focused apical 4-chamber view was used to measure the functional parameters, TAPSE (M-mode) and S’ (pulsed-wave Doppler), and fractional area change (FAC) as well as the size parameters of end-diastolic basal (RVEDDb) and mid (RVEDDm) diameters. Using CMR normal values from the MESA study for males and females separately, magnitudes of abnormality in RV enlargement and dysfunction were determined using SDs from the population mean. Patients were categorized based on CMR results. Values for corresponding 2DE size and function parameters were then calculated for each category using the regression line and cut-offs proposed.
Results: Mean CMR and 2DE values are reported (Table 1). At least moderate correlations (r>0.50) were seen between the functional parameters and CMR RV EF and size parameters and CMR RV EDV. The best correlation was seen between RV EDA and CMR RV EDV (r=0.79). Echocardiographic parameters at 0, 2, 4 and 6 SDs from MESA-derived normal values for males and females separately are shown (Tables 2&3).
Conclusions: Studies combining information from echocardiography and CMR performed in close proximity could enhance the ability to qualify RV size and function other than as normal or abnormal potentially providing more value to the clinician.
Author Disclosures: K. Addetia: None. N. El-Hangouche: None. A.R. Patel: None. M.J. Wilkinson: None. R.M. Lang: None. K.T. Spencer: None.
- © 2014 by American Heart Association, Inc.