Abstract 17523: Incidence of Atrial Fibrillation and Relation with Cardiovascular Events, Heart Failure and Mortality in a European Community-Based Study - Data of PREVEND
Objectives: We investigate the incidence of atrial fibrillation (AF), risk factors of incident AF, and associations with cardiovascular events, systolic and diastolic heart failure and all cause mortality in a contemporary European community-based cohort study.
Methods: In 8265 participants of the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study in Groningen, The Netherlands, incident AF was ascertained on hospital- and study electrocardiograms.
Results: During 9.6±2.4 years of follow up, 265 participants developed incident AF, resulting in an overall AF incidence of 3.3 per 1000 person years. Multivariate determinants for incident AF were age, male sex, hypertension requiring drug treatment, body mass index, previous myocardial infarction and previous stroke (Table). Two interactions were present: male sex * hypertension requiring drug treatment and body mass index * previous myocardial infarction (data not shown). Population attributable risk for incident AF was the highest for hypertension requiring drug treatment (32%), previous myocardial infarction (16%), obesity (body mass index >30kg/m2, 9%) and previous stroke (3%). In multi-variable Cox regression with incident AF as a time-varying covariate, incident AF was associated with cardiovascular events, including stroke, cardiac events and peripheral events (hazard ratio 2.24[1.06-4.75], p=0.035), heart failure (hazard ratio 4.52[2.02-10.09], p<0.001) and all-cause mortality (hazard ratio 3.02[1.73-5.27], p<0.001).
Conclusions: Incidence of AF in the present contemporary cohort was comparable to data of older and mainly US-based studies. Next to well established risk factors, obesity was highly prevalent and significantly increased the risk of incident AF.
Author Disclosures: R.A. Vermond: None. B. Geelhoed: None. N. Verweij: None. R.G. Tieleman: None. P. Van der Harst: None. H.L. Hillege: None. W.H. Van Gilst: None. I.C. Van Gelder: None. M. Rienstra: None.
- © 2014 by American Heart Association, Inc.