Abstract 17520: Emerging Prognostic Factors in Patients with Aortic Stenosis -A Report from the CHART-2 Study
Introduction: Along with the rapid aging of general population, the prevalence of aortic stenosis (AS) has also been increasing worldwide, especially in the developed countries including Japan. The previous studies showed that NYHA class and the severity of AS are the major classical prognostic factors (e.g. valve anatomy, valve hemodynamics). However, since AS is one of the major degenerative diseases of the elderly, it is conceivable that other prognostic factors are also involved in the current practice of AS.
Methods: We examined the prognostic factors for 3-year mortality of 412 consecutive AS patients (mean age 74.9 years, male 52.4%), defined as peak pressure gradient ≥30mmHg, among 10,219 patients with stage B/C/D heart failure (HF) registered in CHART-2 Study (N=10,219).
Results: The prevalence of NYHA I, II, III and IV was 37.7%, 50.9%, 10.8%, and 0.7%, respectively. Renin-angiotensin system inhibitors, beta-blockers, and diuretics were prescribed in 66.7%, 26.9%, and 64.6%, respectively. Crude 3-year mortality was 9.5%, 16.5%, and 49.7% in patients with NYH class I, II and III/IV, respectively (PIII, aortic peak flow (APF)>4.5m/s, serum albumin (Alb), chronic kidney disease (CKD) and use of diuretics was the best model to predict the mortality of AS patients (Table).
Conclusions: The present study demonstrates that in addition to NYHA class and APF, other factors (age, sex, HR, Alb, CKD, and use of diuretics) could also be associated with mortality of AS patients, suggesting that these new factors should also be taken into consideration when evaluating long-term prognosis of AS patients in the current era.
Author Disclosures: K. Sato: None. Y. Sakata: None. K. Nochioka: None. S. Miyata: None. M. Miura: None. S. Tadaki: None. R. Ushigome: None. T. Yamauchi: None. T. Onose: None. K. Tsuji: None. R. Abe: None. H. Shimokawa: None.
- © 2014 by American Heart Association, Inc.