Abstract 17516: Improvement of the Endothelial Function in Patients with Atrial Fibrillation: Effect of Sinus Rhythm Restoration by Catheter Ablation
Background: Endothelial dysfunction has been shown to be correlated significantly with the presence of atrial fibrillation (AF). However, it is not clear to what extent restoration of sinus rhythm by catheter ablation (CA) can improve the endothelial function in patients with AF.
Objectives: The purpose of this study was to examine the serial change in the endothelial function for 6 months periods following CA in AF patients in whom the AF recurrence was not observed. Furthermore, we compared the endothelial functions of these AF patients obtained before and, 3 and 6 months after CA with that of normal control subjects.
Methods: Forty-three normal control patients (control group) and 61 consecutive AF patients who underwent CA of AF and showed no AF recurrence for 6 months after the procedure (AF group) were included. AF group consisted of patients without structural heart disease and the history of AF was 4.7±4.9 years. Endothelial function of these two groups were assessed. All patients assessed their endothelial function by the reactive hyperemia-peripheral arterial tonometry (RH-PAT) and the RH-PAT index (RHI) was measured. The RHI was measured before and 3 month and 6 months after CA in AF group. Then the serial change in the RHI was elucidated in AF group. All measurement of RHI was performed during sinus rhythm both in control and AF groups.
Results: The RHI in control group was 2.21±0.46. The RHI in the AF group before CA was significantly lower than that in control group (2.06±0.49 vs. 2.22±0.46, p=0.036). The RHI in AF group 3 months after CA was significantly improved compared with that before CA (2.40±0.59 vs. 2.06±0.49, p<0.001). The RHI 6 months after CA in AF group was also significantly higher than that before CA (2.24±0.53, vs. 2.06±0.49, p=0.048). The RHI at 3 and 6 months after CA in AF group were not different from that of control group (3 months; 2.40±0.59 vs. 2.21±0.46, p=NS, 6 months; 2.24±0.53, vs. 2.21±0.46, p=NS).
Conclusions: The endothelial dysfunction was present in AF patients even if the sinus rhythm was observed during measurement of RHI before CA. However, the endothelial function in AF patients was improved to the similar level of the normal control subjects when the sinus rhythm was maintained after CA.
Author Disclosures: H. Kanazawa: None. H. Yamabe: Other Research Support; Modest; Medtronic Japan, Nihon Kohden, Boston scientific, St Jude Medical, Japan Lifeline, Fukuda Denshi, Neotec Japan, Shionogi.. S. Sugiyama: None. S. Iwashita: None. T. Hoshiyama: None. M. Ito: None. H. Ogawa: Other Research Support; Modest; AstraZeneca, Astellas, Boehringer lngelheim, Bristol-Myers Squibb, Daiichi Sankyo, Dainippon Sumitomo Pharma, Kowa, MSD, Novartis, Pfizer, Sanofi, Takeda. Other Research Support; Significant; Bayer, Chugai, Otsuka. Honoraria; Modest; AstraZeneca, Bayer, Pfizer, Sanofi, Takeda. Honoraria; Significant; Daiichi Sankyo, MSD.
- © 2014 by American Heart Association, Inc.