Abstract 17449: Left Ventricular Hypertrophy and Reduced Myocardial Function Are Associated with Aortic stiffness Measured by Cardiac MRI: the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Aortic pulse velocity (PWV) is generally considered an intrinsic marker of arterial stiffness. The association of central aortic PWV measured by MRI with cardiac structure and function remains poorly explored. We investigated how central aortic PWV assessed by MRI relates to LV structure and function in the population based study.
Method: Multi-Ethnic Study of Atherosclerosis (MESA) participants at exam5 (2010-2012) were studied. Central aortic PWV was measured by phase contrast (PC) cine MRI at the level of the pulmonary artery bifurcation and black blood sagittal image. LV mass and volume indexed to height1.7, LV ejection fraction (LVEF), and LV mass volume ratio (M/V ratio) were determined by cine MRI. LV circumferential strain (Ecc), LV torsion, and early diastolic strain rate (SRe) were determined from tagged MRI. Linear regression models were used to evaluate the association between PWV and LV parameters after adjusting for demographics and cardiovascular risk factors.
Results: A total of 2018 participants (age 70 ± 9 years, 53% women, 38% White, 10% Chinese, 28% African American, 24% Hispanic) were included in this cross-sectional study. Mean value of PWV was 8.9 ± 4.2 m/s. Distribution of PWV was skewed, so PWV was logarithmically transformed for linear regression models. In multivariable models adjusted for risk factors, higher PWV was associated with less/worse myocardial systolic and diastolic function parameters; LVEF, Ecc, torsion and SRe. Higher PWV was also associated with higher LV mass before and after adjusting multivariable models (Table).
Conclusion: Our observations indicate that higher PWV is related to LV hypertrophy and subclinical myocardial systolic and diastolic dysfunction in multi-ethnic population.
Author Disclosures: Y. Ohyama: None. B. Ambale-Venkatesh: None. A.R. Chught: None. G. Teixido-Tura: None. J. Kim: None. S. Donekal: None. K. Yoneyama: None. O. Gjesdal: None. C. Liu: None. A. Redheuil: None. C. Wu: None. G.W. Hundley: None. D.A. Bruemkie: None. J.A. Lima: Research Grant; Significant; Toshiba Medical Systems.
- © 2014 by American Heart Association, Inc.