Abstract 17405: Influence of Anti-hypertensive Medications on Aortic Peak Stress
Introduction: Aortic disease is treated with medications that lower blood pressure (BP), but may alter stress distributions in the lumen. Computational tools can assist in selecting treatment that will optimally reduce wall stress to avoid or delay a catastrophic event.
Methods: A healthy aorta model was segmented from CT-images and imported in ABAQUS. The tissue was modeled as an exponential neo-Hookean material and underwent two computational analyses, one defining deflated aorta geometry with diastolic BP removed, and one re-loading the aorta to diastolic BP induced by 5 antihypertensive medications: esmolol, labetalol, nicardipine, propanolol, and trichlormethiazide (Fig 1a, 1b). Aortic geometry was divided into 3 parts: ascending, arch and descending portions (Fig 1d). Peak stress in radial, circumferential and longitudinal directions were evaluated for all medications and compared to those generated by a physiological BP.
Results: Stress distributions in the aorta at diastolic BP were found for all medications analyzed (example Fig 1c) and the stress range in each direction was evaluated (Fig 1e). Peak stress varied proportionally with diastolic BP, but reached maximum value in the ascending aorta. Compared with yield stress measured on aortic tissue, the medication-induced peak stresses in a healthy aorta are below the rupture limit (Table 1).
Conclusions: This work aims to develop computational tools that determine maximum stress areas in a patient-specific aorta model to analyze treatments for aortic disease. Our analysis found BP alteration induced in a healthy aorta by 5 medications is below the rupture limit even when considering diastolic loading stress.
Author Disclosures: A. Ward: None. S. Maddalo: None. S. Lavallee: None. V. Flamini: None. A. DeAnda: None. B. Griffith: None.
- © 2014 by American Heart Association, Inc.