Abstract 17369: Telomere Length Predicts Post-Operative Atrial Fibrillation in Patients Undergoing CABG Independently of Chronological Age
Background: Telomere shortening is a marker of cellular senescence, and is associated with cardiovascular disease. Systemic oxidative stress was proposed to reduced telomere length (TL). Paroxysmal atrial fibrillation (PAF) is a redox-sensitive, early clinical complication of CABG, so we hypothesize that telomere length might be a more robust predictor of PAF than chronological age.
Methods: We recruited 475 patients on sinus rhythm and no prior history of PAF undergoing CABG. Blood samples were obtained preoperatively and used to extract DNA and measure relative TL using qPCR, by calculating the Telomere /Single copy gene ratio against albumin (T/S). Systemic oxidative stress was evaluated by measuring plasma malonyldialdehyde (MDA) levels. Patients were monitored for in-hospital post-operative AF events until discharge.
Results: A total of 159 (33.5% of study population) PAF events were recorded. T/S was inversely associated with plasma MDA levels (A). In cox-regression that included T/S, MDA and all the clinical variables related with PAF in univariate analysis, T/S was a strong independent predictor of PAF (RR: 0.566 [95%CI: 0.378-0.848], P=0.006) in addition to (and independently of) chronological age (RR: 1.031 [95%CI: 1.013-1.050], P<0.001) (B).
Conclusions: We demonstrate for the first time that telomere length is a strong predictor of post-operative AF in patients undergoing following CABG, independently of chronological age and systemic oxidative stress status. These novel findings highlight the importance of cellular senescence in cardiovascular disease processes and reveal a potential role of telomere length measurement in clinical predictive models.
Author Disclosures: M. Margaritis: None. S. Patel: None. A.S. Antonopoulos: None. L. Herdman: None. M. Petrou: None. R. Sayeed: None. G. Krasopoulos: None. K.M. Channon: None. B. Casadei: None. C. Antoniades: None.
- © 2014 by American Heart Association, Inc.