Abstract 17245: The Effect on Vitamin D Levels of Long-term High-dose Treatment With a Concentrated Omega-3 Compound (Omacor®/Lovaza®) in Patients Hospitalized With a Myocardial Infarction
Background: Several studies have demonstrated an inverse relationship between cardiovascular risk and levels of vitamin D and omega-3.
Objectives: To assess the impact of high-dose treatment of concentrated omega-3 (ethylester form) on serum vitamin D measured as 25-hydroxyvitamin D [25(OH)D] in 288 patients hospitalized with a myocardial infarction who were randomly assigned into a daily dose of either 4 g highly concentrated omega-3 fatty acids (114 patients) or corn oil (114 patients), administered in a double-blind manner over 12 months. Four mg of alfa-tocopherol was added to each capsule to protect against fatty acid oxidation. Supplementation with other fish-oil products was discontinued. 25(OH)D was measured at baseline, at 6 weeks and 12 months follow-up. Changes in 25(OH)D were compared statistically.
Results: Median 25(OH)D levels in the two groups are shown in Table 1. The increase in 25(OH)D was statistically significant in both treatment groups at 12 months; p < 0.001 for n-3 polyunsaturated fatty acids (PUFAs) and p = 0.011 for corn oil. A statistical significant rise in 25(OH)D was already apparent in the n-3 PUFA patients at 6 weeks follow-up (p < 0.001). There was no significant difference between intergroup changes after 6 weeks intervention (p = 0.867) or after 12 months intervention (p = 0.267) (Mann-Whitney Rank Sum Test).
Conclusion: A statistical significant early rise in vitamin D at 6 weeks follow-up was noted in the omega-3 group of patients, persisting at 12 months, but these changes were not reflected as compared to corn oil, probably due to the fact that both compounds are biologically active.
Author Disclosures: P.A. Naesgaard: None. H. Grundt: None. C. Brede: None. D.W. Nilsen: None.
- © 2014 by American Heart Association, Inc.