Abstract 17203: Increasing Age, Arterial Stiffness, and Ambulatory Blood Pressure
Background: Ambulatory blood pressure (ABP) is associated with an increased risk of cardiovascular disease (CVD) events and mortality. Age is positively associated with higher ABP, particularly systolic ABP. The physiological basis for the association between age and ABP is incompletely understood, and no studies to our knowledge have examined the contributions of arterial stiffness to the age-ABP association. Our objective was to examine whether arterial stiffness might explain the association between increasing age and ABP.
Methods: The Masked Hypertension Study is an ongoing population study of employed adults in New York without CVD, renal failure, or treated hypertension. Clinic BP (CBP), 24-hr ABP, and carotid-femoral pulse wave velocity (PWV) were assessed in 225 participants. Three manual CBP measurements were obtained on three separate occasions (total 9 readings) over a 3-week period and averaged. ABP was assessed using a SpaceLabs 90207 monitor (Snoqualmie, WA). PWV was measured using a SphygmoCor device (AtCor, Itasca, IL).
Results: Of the 225 participants, 90 (40%) were male, 12 (5.3%) were African American, and 29 (12.9%) were Hispanic. Mean ± SD age and body mass index (BMI) were 44.4 ± 10.3 years and 26.4 ± 4.6 kg/m2, respectively. Mean ± SD systolic/diastolic CBP was 115 ± 12 /75 ± 8 mmHg and ABP was 121 ± 11 /77 ± 7 mmHg. The correlation between age and PWV was 0.44 (p<0.001), and between age and awake systolic/diastolic ABP were 0.14 (p=0.041)/0.15 (p=0.028). The positive associations of age with systolic and diastolic ABP in a sex, race/ethnicity, and BMI-adjusted model were completely attenuated after further adjusting for PWV (see Table). In contrast, PWV was significantly associated with awake systolic and diastolic ABP after multivariable adjustment.
Conclusions: The associations between age and elevated BP outside of the clinic setting may, in part, be explained by age-related increases in arterial stiffness.
Author Disclosures: M. Abdalla: None. L. DiCola: None. P. Muntner: Research Grant; Significant; Amgen, Inc. Consultant/Advisory Board; Modest; Amgen, Inc. K.M. Diaz: None. D. Shimbo: None. J.E. Schwartz: None.
- © 2014 by American Heart Association, Inc.