Abstract 17183: Characterization of epicardial adipose tissue in Ischemic Heart Disease: a CMR study
Introduction: Epicardial adipose tissue (EAT) has endocrine and paracrine properties due to its close relationship to the adjacent myocardium. Cardiac magnetic resonance (CMR) provides accurate quantification of EAT even in misshapen hearts.
Objectives: To assess EAT volume in patients with ischemic heart disease and its correlations with structural, functional and clinical features in this group of patients.
Methods: Patients referred for CMR for any clinical reason during a 1-year period with a CMR diagnosis of ischemic heart disease were consecutively included. In each case, CMR was performed with a GE 1.5 T magnet. EAT was manually traced in each case covering both ventricles from the end diastolic phase in the SSFP-B short axis images. The EAT volume was calculated multiplying the area subtended by the slice thickness.
Results: Thirty-seven patients were included. Mean age was 59,7 (12,7) years and 81% were male. The most common indication for CMR was viability assessment- 60% of cases. CMR changed a previous diagnosis of myocarditis or non-ischemic cardiomyopathy in 14.3% of cases. Mean LVEF was 42.8% (13.7). Involved myocardium segments were viable in 18.9% of cases. Mean EAT volume was 109.4 ml (46.1). Mean indexed LV volumes were above normal- 111.8 (38,1) and 69.6 (38) ml/m2, respectively while RV index volumes were normal. EAT did not correlate with age, sex or severely reduced LVEF. EAT volume was lower in normal weight patients (the table). A positive correlation was found between EAT and LV mass and RV index volumes.
Conclusions: In patients with ischemic cardiomyopathy, epicardial adipose tissue volume does not correlate with age or LVEF, even if LVEF is severely reduced. LV volumes are increased. RV volumes are normal and they show a positive correlation with EAT volume.
Author Disclosures: M. Luaces: None. A. Cely: None. N. Zareba: None. P. Marcos-Alberca: None. B. Cabeza: None. L. Pérez de Isla: None. C. Macaya: None.
- © 2014 by American Heart Association, Inc.