Abstract 17181: Gender-related Differences in the Clinical Findings and Outcome of Arrhythmogenic Right Ventricular Cardiomyopathy
Backgrounds: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease associated with lethal ventricular arrhythmias (VT/VF) and heart failure (HF). In all reported series, ARVC is prevalent in men. However, little is known regarding the impact of gender on the heterogeneous clinical profile and prognosis of ARVC.
Objectives: The goal of this study was to assess gender-related differences in patients with ARVC.
Methods and Results: A total of 110 patients with ARVC who fulfilled the Task Force criteria (mean 46 years, range 15 to 73) were enrolled. All patients were probands. Male patients had a 3:1 predominance (75%). At initial evaluation, age, family history, 12-lead electrocardiogram (ECG) findings, late potentials by signal-averaged ECG, left ventricular ejection fraction (EF) and right ventricular EF were comparable between men and women. In the patients underwent electrophysiological study (n = 97), inducibility of sustained ventricular tachycardia was more frequent in men than in women (75% vs. 45%, p = 0.02). During a mean follow-up period of 10.8 ± 7.8 years, VT/VF occurred in 93 patients. Hospitalization for HF was documented in 27 patients, and 17 patients died from a cardiac cause. Kaplan-Meier analysis, considering patients’ lives since birth, revealed that female patients were at decreased risk for VT/VF and increased risk for HF hospitalization compared with male patients. (VT/VF; 63% vs. 92%, HF hospitalization; 37% vs. 20%, respectively, Figure 1). Of note, subanalysis using combination of gender and age showed that the risk for HF hospitalization was the highest among female patients ≥50 years old at initial evaluation, compared with female patients <50 years or with male patients (p = 0.01, Figure 2).
Conclusions: Women with ARVC showed a higher risk of HF hospitalization, especially in those ≥ 50 years old, compared with men.
Author Disclosures: Y. Kimura: None. T. Noda: None. M. Wada: None. I. Nakajima: None. K. Ishibashi: None. K. Miyamoto: None. H. Okamura: None. T. Aiba: None. S. Kamakura: None. S. Yasuda: None. H. Ogawa: None. K. Kusano: None.
- © 2014 by American Heart Association, Inc.