Abstract 17177: Self-rating Depression Scale Score as an Inverse and Independent Predictor of Successful Smoking Cessation with a Pharmacological Treatment for Nicotine Addiction
Background: Smoking cessation (SC) rapidly decreases the risk of cardiovascular events. However, the short-term SC rate with a pharmacological agent such as nicotine patch (NP) or varenicline is only about 50% or less. The impact of a depressive state on the short-term SC rate in patients receiving pharmacological treatment for nicotine addiction is not fully clarified.
Methods and Results: To determine the relationship between the self-rating depression scale (SDS) score and the short-term SC, we performed a prospective study. A total of 1,050 consecutive patients, who visited the SC clinic for the first time, were screened, and a total of 675 patients gave informed consent and took an SDS test. A total of 300, 300, and 75 patients received NP, varenicline, and no pharmacological agent, respectively. After the 12-week standard SC program, the SC rates with NP (58.3%) and varenicline (60.0%) were markedly higher than that without any pharmacological agent (2.7%) (P<0.0001). Then, we divided patients with NP or varenicline (n=600) into two groups: successful (n=355) and unsuccessful (n=245) SC groups. There was no significant difference in a male gender (69.3 versus 64.9%), the Brinkman index (888±27 [SD] versus 894±32), NP treatment (49.2 versus 51.0%), and varenicline treatment (50.7 versus 49.0%) between successful and unsuccessful SC groups. However, age (59±13 versus 55±13 y, P=0.0008) and smoking duration (38±12 versus 35±12 y, P=0.011) were significantly higher, and daily consumption of tobacco (24.0±11.4 versus 26.4±11.8, P=0.016), and scores of the Fagerström Test for Nicotine Dependence (FTND) (6.9±2.0 versus 7.6±1.9, P<0.0001), and SDS (37.7±10.1 versus 40.2±10.1, P=0.0042) were significantly lower in successful compared with unsuccessful SC group. Stepwise multivariate logistic regression analysis revealed that the FTND score (odds ratio [OR], 0.74 per 1-SD increase; 95% confidence interval [CI], 0.62-0.88; P=0.0008) and SDS score (OR, 0.84 per 1-SD increase; 95% CI, 0.71-0.999; P = 0.0491) were inversely and independently associated with successful SC.
Conclusions: The SDS score, an indicator of depressive state, may serve as an inverse predictor of successful SC in combination with the FTND score of nicotine dependence.
Author Disclosures: S. Ura: None. H. Wada: None. N. Satoh-Asahara: None. M. Akao: None. M. Abe: None. K. Ono: None. T. Morimoto: None. A. Shimatsu: None. Y. Takahashi: None. K. Hasegawa: None.
- © 2014 by American Heart Association, Inc.