Abstract 17165: Impact of Physical Activity Levels on Death or Heart Failure Related Hospitalizations in Patients with Heart Failure: a Sub study of the HART Trial (NCT00018005)
Background: It is agreed that aerobic exercise can improve the outcome of patients with heart failure (HF). However, the impact of sedentary life style on HF outcome among patients not participating in a regimented aerobic exercise program is unknown.
Methods: We analyzed data from Heart failure Adherence and Retention Trial (HART) which enrolled NYHA class II and III HF patients. Questionnaire was used to assess self-reported weekly physical activity levels. Patients were divided into 3 groups: sedentary (walking < 10 min/wk), partially active (10-119 min/wk), and active (≥ 120 min/wk). Univariate Cox regression models were used to determine significant predictors of the primary outcome of death or HF hospitalization. Multivariate Cox regression model was fitted to assess the impact of physical activity level on the primary outcome, adjusting for significant univariate predictors.
Results: HART enrolled 902 patients. Data on physical activity were available on 673 patients. There were 246 primary outcome events. Median follow up was 30 months. After adjusting for univariate predictors of outcome, there was no difference in outcome between sedentary and partially active patients (HR 1.12; P=0.48). There was a non-statistically significant trend towards worse outcomes in sedentary patients compared to active patients (HR 1.43, P=0.09) (Figure 1).
Conclusion: Regular physical activity appears to be associated with lower risk of death or HF hospitalization in patients with HF who are not participating in a regimented aerobic exercise program, consistent with the “on-treatment” analysis of the HF-ACTION trial. Sedentary life style does not seem to be associated with increased risk of death or HF hospitalization as compared to partially active life style.
Author Disclosures: A. Mangla: None. R. Doukky: None. J. Kaplan: None. E. Segawa: None. E. Avery: None. D. Richardson: None. L.H. Powell: None.
- © 2014 by American Heart Association, Inc.