Abstract 17099: Hyperuricemia Could Predict Resistance in Weight Loss and Weight Loss-induced BP reduction Associated With Sympathetic Activation
Introduction: Hyperuricemia (hyperUA) is a cardiovascular risk and uric acid (UA) levels may predict future hypertension. In this study, we evaluated the relationships between UA levels and future weight loss (WL) and blood pressure (BP) reduction with WL regimens, and the mechanism of chronic WL on UA levels.
Methods: Obese, mild hypertensive men (n=154) on no medications were measured BMI, blood pressures (BP), UA, fasting glucose, plasma norepinephrine (NE), insulin (INS) and HOMA-IR before and every 6 month over 2 yrs with WL regimens (mild cadiet + exercise). Significant WL was defined as ≥10% WL of entry BMI at 2 yrs. HyperUA was defined as >mean+1SD (4.3 + 1.5 mg/dL).
Results: Significant WL was observed in 47.8% at 1 yr and 61.7% at 2 yrs. HyperUA was noted in 64.3% at baseline, 43.3% at 1 yr, and 29.9% at 2 yrs. UA levels, plasma NE, BMI and BP levels at entry were greater in the non-WL group compared to the WL group, whereas HOMA-IR at entry were similar between the WL and non-WL groups. BMI, BP, UA, NE and HOMA-IR decreased significantly with WL over 2 yrs in all subjects, but the magnitudes of decreases in all parameters were significantly greater in the WL group compared to the non-WL group. The hyperUA group showed smaller success rates in WL at 2 yrs (54.5% vs. 74.5%, P<0.05) and smaller %decreases in BMI, BP, UA, NE and HOMA-IR over 2 yrs compared to the NormoUA group. Changes in UA over 2 yrs correlated with changes in BMI, systolic BP, plasma NE and fasting glucose (all, P<0.05). UA at entry correlated with changes in BMI and BP over 2 yrs(both P<0.05). In the WL group regardless of UA levels, during WL, significant reductions in NE, BMI, UA, HOMA-IR and BP were observed in this order.
Conclusions: These results demonstrate that chronic WL over 2 yrs was effective to decrease UA levels in obese subjects. UA levels might predict the effects of WL program on WL and BP reduction. Previously, we reported that diet and exercise had different effects on the improvement on all parameters, but suppression on sympathetic activation was always observed before UA and BP reductions. Therefore, suppression of sympathetic nervous activation, but not improving insulin resistance (IR) by WL, might be a major role in UA reduction, and IR might be related to WL-induced BP reduction.
Author Disclosures: K. Masuo: None.
- © 2014 by American Heart Association, Inc.