Abstract 17052: Significance of Micro-vessels Within Atherosclerotic Coronary Plaques: a Color-coded Intravascular Ultrasound Study
Background and Purpose: It has been documented that neovascularization in atherosclerotic plaques is associated with plaque vulnerability. This study was to examine tissue characteristics of plaque with micro-channels detected by optical coherence tomography (OCT). The tissue was assessed by use of a commercially available color-coded intravascular ultrasound (IVUS), iMap software.
Method: A total of 61 coronary plaques was classified into two groups: plaques with micro-channels (Pm, n=37) and without (Po, n=24). Micro-channel was defined as a tiny tubule with a diameter of 50 to 300 micrometers detected over 3 or more frames in OCT. Plaques over a length of 5mm were also analyzed by IVUS at the corresponded portion of the OCT imaging. The i-Map software identified four types of tissue component such asfibrotic, lipidic, necrotic, and calcified areas.
Result: There was no significant difference in plaque and vessel volume between the two groups. However, % content of fibrotic area was significantly smaller in group Pm than that in group Po (68.33%±11.25% vs. 76.12±20.24%, p=0.039), while % content of necrotic area was significantly larger in group Pm than that in group Po(13.44%±5.79% vs. 8.29%±3.50%,p=0.022). There was no significant difference in lipidic and calcified areas between the two groups.
Conclusion: Plaques with micro-channels were more vulnerable than those without. These data suggested that micro-channels within coronary plaque might be related to plaque vulnerability.
- Intravascular ultrasound/Doppler
- Cardiovascular imaging
- Coronary artery disease
- Percutaneous coronary intervention (PCI)
Author Disclosures: T. Nishida: None. T. Nishida Takayama: None. T. Hiro: None.
- © 2014 by American Heart Association, Inc.