Abstract 16817: Body Fatness is Associated With Carotid Intima-Media Thickness in Non-Obese Adults
Background: Adults with normal body mass index (BMI) but high body fat percentage have higher cardiovascular disease (CVD) risk than subjects with normal weight and low fat mass. However, the association of body fat and subclinical atherosclerosis in carotid artery in non-obese individuals has not been reported. Our aim was to test the hypothesis that even in the absence of obesity by BMI, IMT correlates with total fat and fat distribution. Additional aim was to test the possible interaction between gender, fat and IMT.
Methods: We measured the carotid intima-media thickness (IMT) with ultrasound in three different locations (common carotid artery, bifurcation and internal carotid artery) and created a composite value averaging all IMT measurements in 135 healthy volunteers with a BMI <30 kg/m2 and without major CVD risk factors. Body composition was measured by dual-energy x-ray absorptiometry. We did raw and multivariate analyses adjusting for age, gender, height squared, systolic blood pressure, total cholesterol, and total muscle mass.
Results: Age (mean ±SD) was 44 ±9 yrs, range 29-65 yrs, 56% women, 45% Whites, 44% Asians, 10% Hispanic, 1% African-American. There was no statistically significant interaction between gender, fatness and IMT. Composite IMT was 0.50 ±0.11 mm, median 0.49, IQR 0.42-0.56. Total fat and centrally distributed fat were positively associated with IMT. (Figure)
Conclusion: In healthy, non-obese adults without major CVD risk factors, greater body fat content was independently and directly associated with higher IMT. The association between body fat and IMT appeared to be different between genders, but the study was not powered to assess gender differences.
Author Disclosures: H. Podrouzkova: None. P. Wohlfahrt: None. V. Somers: None. L. Hinshaw: None. O. Sochor: None. I. Kullo: None. F. Lopez-Jimenez: None.
- © 2014 by American Heart Association, Inc.