Abstract 16542: Gender Differences in Non-BMI Predictors of Left Ventricular Myocardial Relaxation in Non-Obese Individuals
Introduction: Previous studies indicate patients with metabolic syndrome (MetS) and obese might be at risk for left ventricular (LV) diastolic dysfunction. However, little is known about which metabolic factors contribute to the development of LV dysfunction in those without obesity, diabetes mellitus, and/nor cardiovascular disease.
Hypothesis: Normal-weight individuals with adverse metabolic status may have any different non-body mass index predictors of left ventricular diastolic dysfunction.
Methods: Participants without obesity (body mass index ≥ 25 kg/m2), diabetes mellitus, systolic dysfunction, or other heart diseases underwent a thorough physical examination including tissue Doppler echocardiography. A peak early mitral annular velocity (e′) of < 5.0 was designated as indicating abnormal LV myocardial relaxation (LVMR). We performed single and multiple logistic regression analyses of e′ and cardiovascular risk factors, including MetS factors and indicators of major organ dysfunction.
Results: A total of 806 individuals (mean age, 63 ± 13 years) participated, of which 141 (17.5%) had MetS. Of the study population, 30.2% of men (127/421) and 3.3% of women (14/385) had abnormal LVMR. Multiple logistic regression analysis revealed aging (odds ratio [OR] 1.08, P < 0.01), abnormal waist circumference (WC) (OR 2.80, P < 0.01) and renal dysfunction (OR 2.14, P < 0.01) to be predictors of abnormal LVMR. In Mets factors, WC was related to abnormal LVMR in men (OR 3.70, P < 0.01), diastolic blood pressure (DBP) was related to abnormal LVMR in women (OR 4.00, P = 0.01). During a mean follow-up of 52 months, 12 individuals (1.5%) were hospitalized with heart failure; of these, 9 had abnormal LVMR at initial examination.
Conclusions: In Mets factors, WC in men and DBP in women were independent risk factors for abnormal LVMR without obesity. Therefore, WC and DBP might be useful for predicting diastolic heart failure during routine physical checkups.
Author Disclosures: H. Sekiguchi: None. K. Shimamoto: None. M. Kimura: None. F. Tatsumi: None. E. Watanabe: None. M. Kawana: None.
- © 2014 by American Heart Association, Inc.