Abstract 16445: Reference Echocardiographic Measurements in Free-Living Adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Background: Current normal reference values for echocardiography are derived from North American or European populations, and it is not known if these are applicable to the multiethnic constitution of Brazilian and South American populations.
Objective: We aimed to describe reference values for echocardiographic measurements in a contemporary cohort of middle-aged and elderly free-living Brazilians.
Methods: Echocardiographic studies from 3234 participants (33% of those for whom echocardiography was available) were read in the ELSA Echocardiography Reading Center. Their demographic characteristics did not differ substantially from remaining participants of similar age in the ELSA-Brasil cohort - a study of Brazilian public servants aged 35 to 74 years. Among these, we identified a reference normal sample of 950 (29%) participants (56±10 years; 40% men) after excluding those with prevalent hypertension (51%), diabetes (27%), metabolic syndrome (45%), self-reported cardiovascular disease (13%), or echocardiographically determined myocardiopathy or significant valvular disease (13%).
Results: The Table describes sex-specific mean±SD values from the reference normal sample. Mean values for structural measurements were larger for men, but systolic function and mitral annular tissue Doppler measurements were similar. The majority of measurements were within the normal range of other populations.
Conclusion: Although results in this sample, which we believe to be the largest drawn to date from an apparently normal Latin American population, are mostly similar to those of other international reference samples, particularities exist that may relate to its multi-ethnic nature or to other regional characteristics. We believe that these results are suitable for use as regional normative values and for international comparisons.
Author Disclosures: M. Foppa: None. A.B. Santos: None. C.M. Freire: None. L.P. Fernandes: None. P.R. Vasconcellos-Silva: None. R. Sharovsky: None. L.M. El Aouar: None. J.C. Pires: None. M. Bessel: None. J.G. Mill: None. P.A. Lotufo: None. B.B. Duncan: None.
- © 2014 by American Heart Association, Inc.