Abstract 16428: Subclinical Atherosclerosis and Obesity Phenotypes in Mexican Americans
Despite a robust association between carotid intima-media thickness (cIMT) and cardiovascular disease (CVD), the influence of obesity on subclinical atherosclerosis is not well understood and data are inconsistent. This may be related to varying cardiometabolic risk among obese individuals. Data on CVD in Mexican Americans are likewise conflicting and despite elevated obesity prevalence, reported death rates are no higher than Whites. We hypothesize that cardiometabolic risk modulates the obesity effect on early atherosclerosis development in Mexican Americans and that the influence of cardiometabolic risk is more important than body mass index (BMI) alone.
METHODS: Participants (n=493) were drawn from the Cameron County Hispanic Cohort, a Mexican American cohort in Texas on the US-Mexico border. Metabolic health was defined as having < 2 of the following cardiometabolic abnormalities: BP ≥ 130/85; triglyceride ≥ 150 mg/dL; high-density lipoprotein cholesterol <40 mg/dL (men) or <50 mg/dL (women); fasting glucose ≥ 100 mg/dL; homeostasis model assessment of insulin resistance value >5.13; or high sensitivity C-reactive protein >0.1 mg/L. Carotid ultrasound was performed and cIMT was measured in a blinded manner.
RESULTS: Mean age was 53±13 years (68% female). Obesity prevalence was 55%. cIMT did not differ between nonobese and obese metabolically healthy phenotypes, or between nonobese and obese metabolically unhealthy phenotypes (Figure).
CONCLUSION: In Mexican Americans, cardiometabolic risk has a greater effect on early atherosclerosis development than BMI alone, and nonobese but metabolically unhealthy participants had similar development of subclinical atherosclerosis as their obese counterparts. This study highlights the importance of assessing metabolic risk in Mexican Americans regardless of BMI. Interventions to maintain metabolic health among obese patients may be a more important goal than weight loss alone.
- Subclinical atherosclerosis
- Metabolic syndrome
- Carotid intima-media thickness (CIMT)
Author Disclosures: S.T. Laing: None. B. Smulevitz: None. K.P. Vatcheva: None. D.D. McPherson: None. J.B. McCormick: None. S.P. Fisher-Hoch: None.
- © 2014 by American Heart Association, Inc.