Abstract 16278: Short-Term Effects of Lifestyle Changes on HDL and the Total Cholesterol / HDL Ratio in the Heart of New Ulm Project
Objective: With the limited benefits of most medications that raise HDL, lifestyle changes are of particular interest. To examine the association between changes in individual and composite measures of lifestyle factors with changes in high density lipoprotein (HDL) and total cholesterol/HDL ratio (Chol/HDL) over 2 years.
Method: The Heart of New Ulm Project is a 10-year community-based CVD prevention program. Our study sample consisted of 1659 adult residents who attended screenings in 2009 (baseline) and 2011. The primary independent measures were change in an optimal lifestyle score (OLS) and change in each OLS component (smoking, fruit/vegetable, alcohol, physical activity, and BMI). Change in the OLS and components were categorized as improved, declined, or stable. Linear regression models predicting changes in HDL and Chol/HDL over 2 years were run with OLS change category as the predictor. A separate model was also run examining the association between change in each OLS component, HDL, and Chol/HDL. Models were adjusted for relevant baseline covariates.
Results: Weight loss, increased physical activity, and quitting smoking were strongly associated with improved HDL. On average, those who were obese in 2009 and not obese in 2011 lowered their Chol/HDL by 0.25 and increased their HDL by 3.21mg/dL more than those with stable BMI. Those who quit smoking decreased their Chol/ HDL ratio on average 0.49 more than those whose smoking status remained unchanged. Those younger than 50 years who increased their physical activity decreased their Chol/HDL on average 0.20 more than those whose physical activity remained stable. A combination of improvements in any of the three factors showed a moderate impact on raising HDL compared to those who remained stable.
Conclusions: In the setting of a rural population-based prevention program, weight loss, smoking cessation, and sufficient physical activity were associated with favorable improvement in HDL and Chol/HDL ratio.
Author Disclosures: A. Sillah: None. A.C. Sidebottom: None. M.D. Miedema: None. T. Knickelbine: None. J.L. Boucher: None. J.J. VanWormer: None.
- © 2014 by American Heart Association, Inc.