Abstract 16134: Impact of Perioperative Management on Prevention of Prosthetic Valve Detachment After Aortic Valve Replacement for Patient With Takayasu’s Arteritis
Background: Patients with Takayasu’s arteritis sometimes complain of aortic regurgitation. We investigate the impact of perioperative management on prevention of prosthetic valve detachment after aortic valve replacement for patient with Takayasu’s arteritis.
Methods: Eighty-six Takayasu’s arteritis patients who underwent aortic valve replacement were enrolled in this study. Thirty-eight patients (44.2%) were administered steroid preoperatively. Preoperative steroid dose was 1-9mg of prednisolone per day in 9 patients (10.5%), 10-19mg/day in 21 (24.4%), and 20-30mg/day in 8 (9.3%). Follow-up period was 12.1+-8.1 years.
Results: Forty-four patients (51.8%) had active inflammation of the aortic valve. Survival rate was 77.1% at 10 years and 56.6% at 20 years. Prosthetic valve detachment free rate was 80.8% at 10 years and 71.1% at 20 years.
In multivariate study, active inflammation, young age and high CRP at 30 days after operation were risk factors for valve detachment (Table).
Conclusion: Inflammation is related to prosthetic valve detachment after aortic valve replacement for patient with Takayasu’s arteritis. Perioperative aggressive inflammation control using steroid is important to prevention of detachment.
Author Disclosures: S. Sato: None. K. Minatoya: None. T. Fujita: None. T. Oda: None. Y. Seike: None. T. Itonaga: None. Y. Shimahara: None. H. Hata: None. H. Sasaki: None. H. Ishibashi-Ueda: None. J. Kobayashi: None.
- © 2014 by American Heart Association, Inc.