Abstract 16098: Risk Factors for Frequent Premature Atrial Complexes in a Ten Year Holter Cohort
Introduction: Frequent premature atrial complexes (fPACs) predict increased risk of Atrial Fibrillation (AF). Risk factors for fPACs are not well established.
Hypothesis: Patients with fPACs (≥100/day) will differ significantly from those without fPACs (<100/day).
Methods: Holter recordings obtained between 2000 and 2010 of 1357 veterans free of AF were analyzed for premature atrial activity. Holter groups with fPACs and infrequent PACs were compared for differences in baseline characteristics obtained from EMR. Statistical comparisons were made using Chi square and student t-tests. Multivariate logistic regression analysis was used adjust for confounders.
Results: Mean age of the study population was 64.3 years and 93% were male. Ninety one percent had at least 1 PAC per 24 hour ECG study period. Patients with fPACs were older (mean age 71.4 versus 60.3 years) and had higher mean maximum and a lower mean minimum heart rate. Hypertension, CAD, CHF and COPD were significantly more prevalent in fPAC group. More patients in fPAC group had left atrial enlargement and diastolic dysfunction. Multivariate logistic regression analysis showed age ≥ 75 yrs (OR 4.30, 95% CI 3.33 - 5.56, P <0.001), hypertension (OR 1.50, 95% CI 1.15 - 1.95, P=0.003) and COPD (OR 1.62, 95% CI 1.10 - 2.37, P=0.014) to be independently associated with fPACs. Of those patients who had reliable ECHO parameters available, left atrial enlargement (OR 1.73, 95% CI 1.18 - 2.52, P=0.005) emerged as a significant association of fPAC.
Conclusions: Age, hypertension, COPD and left atrial size are independent risk factors related to fPACs. Further studies are needed to evaluate pathophysiology of these associations.
Author Disclosures: T. Acharya: None. V.K. Ilineni: None. M.S. Bhullar: None. M. Nalbandyan: None. S. Tringali: None. M. Singh: None. E. Carbajal: None. P.C. Deedwania: None.
- © 2014 by American Heart Association, Inc.