Abstract 16060: Usefulness of Magnetic Resonance Feature Tracking to Measure Both Systolic and Diastolic Cardiac Function: Comparison With Pressure Volume Loop Analysis in Animal Study
Background: The noninvasive evaluation of cardiac function remains a challenge. A new modality, feature tracking (FT), offers a novel method of measuring myocardial strain and velocities from cardiovascular MR (CMR) images. We aimed to quantify the left ventricular diastolic and systolic function by using FT- CMR cine acquisitions in comparison with values from cardiac catheterization.
Methods: Porcine ischemic heart models were obtained by using LAD occlusion methods. We subjected 13 porcine models that had both CMR and cardiac catheterization. LV long axis CMR cines were analyzed using FT-CMR software (TomTec, Germany). Myocardial mechanics (diastolic function(DF): peak of early diastolic dv/dt, strain rate, systolic function(SF): peak of negative dv/dt, %strain and strain rate) which obtained from FT-CMR were compared with catheterization parameters (DF: EDP, Tau, EDPVR, peak of negative dp/dt, SF: ESPVR, peak of positive dp/dt). We also examined the correlation with the DF and SF with the %fibrosis and the cardiomyocite sizes from the histological findings.
Result: Arly diastolic dv/dt and strain rate obtained from FT-CMR were correlated with DF parameters [Tau (r=0.64, p=0.002, r=-0.78, p=0.03), EDP (r=-0.77, p=0.003, r=-0.89, p=0.00), peak negative dp/dt (r=0.55, p=0.03, r=0.66, p=0.02), EDPVR (r=-0.71, p=0.01, r=-0.71, p=0.01)] obtained from catheter examination. For SF, negative peak dv/dt and %strain obtained from FT-CMR were correlated with SF parameters [peak positive dp/dt (r=-0.56, p=0.05, r=0.66, p=0.01, r=0.74, p=0.01), ESPVR (r=-0.58, p=0.04, r=0.51, p=0.05, r=0.55, p=0.04)] obtained from catheter examination. Histological analysis demonstrated that %fibrosis was negatively correlated with early diastolic dv/dt (r=-0.71, p=0.01) and the cardiomyocyte cell size of the infarct border area was negatively correlated with negative peak dv/dt (r=-0.65, p=0.02).
Conclusions: Noninvasive diastolic myocardial mechanics, which obtained from FT-CMR were significantly correlated with cardiac catheterization diastolic and systolic parameters, and histological findings, suggesting that the non-invasive FT-CMR has potential usefulness for measuring measuring both systolic and diastolic cardiac functions.
- Cardiac MRI
- Diastolic function
- Myocardial infarction
- Pressure – volume relation
- Magnetic resonance imaging
Author Disclosures: H. Ozawa: None. S. Miyagawa: None. S. Fukushima: None. A. Harada: None. E. Ito: None. A. Saito: None. T. Ueno: None. K. Toda: None. T. Kuratani: None. Y. Sawa: None.
- © 2014 by American Heart Association, Inc.