Abstract 15628: Physically Active Women With Type 1 Diabetes Have Improved Hyperglycemia but Not Overall Glycemic Control
Cardiovascular disease (CVD) is the main cause of mortality in type 1 diabetes (T1D) patients. Chronic hyperglycemia has been linked to progression of coronary artery calcification and CVD events. Physical activity (PA) may improve hyperglycemia in T1D patients. The objective of this study was to analyze the relationship between PA and glucose parameters obtained from Continuous Glucose Monitoring (CGM).
This study included 43 women with T1D who were 33±9 (mean±SD) years of age from the Women, Insulin and Sex Hormones study. Subjects wore a CGM (Dexcom SEVEN PLUS) for an average of 14±12 days. Glycemic control was evaluated by the average mean glucose, percentage of values within target range (70-180mg/dL), hypoglycemic (<70mg/dL), hyperglycemic (>180mg/dL), and hemoglobin A1c (HbA1c). Participants were classified into two categories, met (n=8) or did not meet (n=34) the AHA guidelines for moderate PA of at least 150 minutes or vigorous PA of at least 60 minutes per week.
T1D women who met the PA guidelines had a lower percent of time hyperglycemic and a higher percent of time in the target range, and a smaller standard deviation in the mean glucose (table). There was no difference in HbA1c. In multivariable analysis, the percent of time hyperglycemic was associated with central mean arterial pressure, systolic pressure, and diastolic pressure (p=0.02) when adjusting for age, race, and minutes of PA per week. The percent of time in target was associated with central mean pressure, systolic pressure, and diastolic pressure (p=0.02) adjusting for the same variables.
Despite no difference in overall glycemic control measured by HbA1c, physically active T1D women had less hyperglycemia and spent more time in the target range compared to sedentary women. These were both associated with measures of central arterial stiffness. Therefore, PA may decrease the risk for CVD through specific effects on reduced overnight glucose and variability, not overall glycemic control alone.
Author Disclosures: L.M. Duca: None. T. Brown: None. S. Ruland: None. R. Sippl: None. J. Snell-Bergeon: None.
- © 2014 by American Heart Association, Inc.