Abstract 15508: Relationship between Aerobic Fitness and Arterial Stiffness According to Hypertensive State
Introduction: There has been inconsistent data on the relationship between aerobic fitness and arterial stiffness. Objective of this investigation is to evaluate whether they are significantly associated and whether the relationship differs significantly between hypertensive and non-hypertensive subjects.
Methods: The subjects of the study were adults with no history of clinical cardiovascular diseases and normal exercise test results, who had undergone health screening. Cardiopulmonary function test was done by modified Bruce protocol and maximal oxygen consumption (VO2max) was obtained. Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV).
Results: The subjects were 11557 men and women (M:F=76:24 %) with mean age of 52 ± 5 years and had hypertension in 34 %. Maximal oxygen consumption showed inverse correlation with baPWV (r = - 0.21, p < 0.0001) This relationship persisted (p < 0.001) after adjustment for age, gender, baseline SBP and DBP, VO2max, HbA1C, waist circumference, smoking and lipid profile in multiple regression model. Regression coefficient of VO2max was significantly more negative among hypertensive than non-hypertensive subjects. (-10.8 +/- 0.6 vs. -5.6 +/- 0.3, p for interaction term < 0.0001)
Conclusions: Among subjects without clinical cardiovascular diseases, better aerobic fitness was associated with less arterial stiffness. Its effect seems to be larger in hypertensive patients than in non-hypertensives.
Author Disclosures: J. Sung: None. S. Cho: None. K. Hong: None.
- © 2014 by American Heart Association, Inc.