Abstract 15474: Serum Galectin-3 Level Predicts the Extent of Left Atrial Fibrosis in Lone Atrial Fibrillation Patients
BACKGROUND: Left atrial(LA) interstitial fibrosis is known to have a role in the initiation and maintenance of atrial fibrillation(AF). The role of galectin-3 in the pathogenesis of cardiac fibrosis has been demonstrated in previous studies. We aimed to determine whether serum galectin-3 level is an independent predictor for the extent of left atrial fibrosis detected by delayed-enhancement magnetic resonance imaging(DE-MRI) in lone AF patients.
METHODS: 40 patients [51.50% male, 57 (28- 74) years] with lone atrial fibrillation who underwent DE-MRI were included in the study. Serum galectin-3 levels were measured with ELISA.
RESULTS: Age (r=0.357, p=0.047), body mass index(BMI) (r=0.323, p=0.037), serum galectin-3 levels (r=0.847, p<0.001) and left atrial diameter(LAD) (r=0.610, p<0.001) were found to be significantly correlated with the extent of left atrial(LA) fibrosis in lone AF patients. Robust regression analysis demonstrated that among age, BMI, serum galectin-3 levels and LAD; only serum galectin-3 level (B± SE: 2.97± 0.47, 95% CI: 2.01-3.92, p<0.001) was an independent predictor for the extent of LA fibrosis.
CONCLUSION: Serum galectin-3 level is an independent predictor for the extent of LA fibrosis detected by DE-MRI in lone AF patients. Galectin-3 may serve as a novel therapeutic target in lone AF patients to interfere atrial fibrogenesis.
Author Disclosures: K.M. Gurses: None. M.U. Yalcin: None. D. Kocyigit: None. H. Canpinar: None. U. Canpolat: None. B. Evranos: None. H. Yorgun: None. M.L. Sahiner: None. E.B. Kaya: None. D. Guc: None. M.A. Oto: None. K. Aytemir: None.
- © 2014 by American Heart Association, Inc.