Abstract 15469: Depressive Symptoms are Associated with Arterial Stiffness in Premenopausal Women with Type 1 Diabetes
Cardiovascular disease (CVD) is the primary cause of mortality in people with diabetes. Arterial stiffness is increased in type 1 diabetes (T1D) even in young adulthood. Depression rates are higher in T1D versus non-diabetic (non-DM) people, and in the general population, depressive symptoms correlate with subclinical atherosclerosis. However, little is known about associations between depression and earlier markers of CVD in young adults with T1D. This study evaluated the association between depressive symptoms and arterial stiffness in premenopausal women with and without T1D.
The study included 132 women (44 with T1D, 88 non-DM) between 18-45 years of age (mean age ± SD = 33 ± 8 years in T1D, and 30 ± 6 years in non-DM, p=0.03). Women with T1D had a mean diabetes duration ± SD of 21 ± 9 years. Depressive symptoms were assessed using the Beck Depression Inventory II depression scale (BDI II) and BDI II subscales (somatic, affective, and cognitive). Arterial stiffness was assessed by measuring carotid-femoral pulse wave velocity (PWV) and brachial artery distensibility (BrachD).
Both PWV (p=0.006) and BrachD (p<0.0001) were significantly more adverse in women with T1D in univariate comparisons. The total BDI II (p=0.01), somatic subscale (p=0.004) and affective subscale (p=0.04) but not the cognitive subscale (p=0.29) were increased in women with T1D. In multivariable analysis (Table), total BDI II and the somatic subscale were significantly associated with higher PWV but were not associated with BrachD. The affective and cognitive subscales were only associated with PWV and BrachD in women with T1D (p-value for interactions with diabetes status all <0.10).
In young women with T1D, presence of depressive symptoms is associated with worse arterial stiffness. Depression is a modifiable risk factor, and so identification and treatment of depression in this population could be useful in improving CVD morbidity.
Author Disclosures: S. Majidi: None. S. Ruland: None. L. Duca: None. R. Sippl: None. J. Snell-Bergeon: None.
- © 2014 by American Heart Association, Inc.